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Progress in Chemistry 2011, Vol. 23 Issue (5): 963-973 Previous Articles   Next Articles

• Review •

Artificial Oxygen Carriers

Yin Xiaochun, Wang Rongmin, He Yufeng, Zhu Yongfeng, Pei Fei   

  1. Key Laboratory of Eco-Environment-Related Polymer Materials of Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China
  • Received: Revised: Online: Published:
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Because of the increasing demand for blood and the emergence of unsafe issues in allogeneic blood transfusion, blood substitutes are attracting increasing interest in chemistry and medical science. Based on the knowledge of the structure and functions of hemoglobin-a typical natural oxygen carrier, many artificial oxygen carriers have been synthesized and applied to clinical trails. Artificial oxygen carriers include perfluorocarbon, hemoglobin-based oxygen carrier, synthetic heme and its polymer metal complexes. Although most of the perfluorocarbons could not be applied as blood substitutes, their applications as medicine are still continued because of their therapeutic effect. In order to reduce unwanted side-effects of hemoglobin-based oxygen carriers, hemoglobin has been modified by many methods, such as chemical modification, microencapsulation, recombinant technology, biomimetic nanotechnology, etc. Among all of the above hemoglobin-based oxygen carriers, the particle size of hemoglobin vesicles (HbV) is relatively larger in the simulation of the structure of the red blood cell. It represents one of the tendency of the progress of hemoglobin-based oxygen carriers. Most of synthetic hemes, such as pocket porphyrin metal complexes, are only dissolved in organic solvents. In order to increase their water-solubility, synthetic hemes have been conjugated with albumin, xylitol enzymes and cyclodextrin and so on. The results of animal trial showed that these polymer metal complexes could transport dioxygen in the animal body. Beside to be used as the blood substitutes in clinical trails, artificial oxygen carriers have other potential clinical uses, such as cancer therapy, organ transplantation and prevention of ischemia/reperfusion injury of tissues and organs.

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[1] Kobayashi K, Tsuchida E, Horinouchi H. Artificial Oxygen Carrier. Tokyo: Springer, 2005. 1-18
[2] Klein H G. Transfusion Medicine. Blood Substitutes(ed. Winslow R M). London: Academic Press, 2006. 17-41
[3] 黄宇彬 (Huang Y B), 景遐斌 (Jing X B), 石全 (Shi Q), 孙静 (Sun J), 陈学思(Chen X S). 中国医疗器械信息(China Medcial Device Information), 2009, 15(5): 5-10
[4] Tsuchida E. Blood Substitutes, Present and Future Perspectives (ed. Tsuchida E). Amsterdam: Elsevier, 1998, 1-15
[5] Petz L D, Kleinmann S, Swisher S N, Spence R K, Strauss R G. Clinial Practice of Transfusion Medicine. 3rd ed. NY: Churchill Livingstone, 1996. 563-579
[6] Lu X L, Zheng C Y, Shi X D, Wang Y Q, Suo X Y, Yu P Z, Xu Y H, Ma T M, Su Z G. Artif. Cells. Blood. Substit. Immobil. Biotechnol., 2005, 33(2): 83- 99
[7] Zhu X L, Chu W, Fan D D, Dan N, Chen C, Wang T W, Wang F. Artificial Cells, Blood Substitutes and Biotechnology, 2007, 35(5): 518-532
[8] Huang Y B, Jing X W, Chen X S. New Type of Oxygen Transport boby-Polymer/ Micronano-particles of Hemoglobin. Chengdu: Chinese Biomaterials Congress, 2010, S8-1-1
[9] Scholer M, Frietsch T, Jambor C, Knels R. Dtsch. Med. Wochenschr., 2010, 135(12): 575-581
[10] 王红梅(Wang H M), 王保龙(Wang B L), 姚萍(Yao P), 苏虹(Su H). 临床输血与检验(J. Clin. Transfus. Lab. Med.), 2005, 7(4): 314-317
[11] 路秀玲(Lu X L). 生物工程学报(Chinese Journal of Biotechnology), 2006, 22(1): 7-18
[12] 王雁峰(Wang Y F), 潘继伦(Pan J L), 俞耀庭(Yu Y T). 生物医学工程学杂志(J. Biomed. Eng.), 2004, 21(3): 490-494
[13] Chang T M S. Blood Substitutes:Principle,Methods,Products and Clinical Trials. Basel: Karger Publisher, 1997. 216-231.
[14] Paoli M, Liddington R, Tame J, Wilkinson A, Dodson G. J. Mol. Biol., 1996, 256(4): 775-792
[15] 査锡良(Zha X L), 周春燕(Zhou C Y). 生物化学(Biochemistry). 北京: 人民卫生出版社(Beijing: People's Health Publisher), 2009, 26-28
[16] Daltrop O, Ferguson S J. J. Biol. Chem., 2004, 279(44): 45347-45353
[17] 王荣民(Wang R M), 朱永峰(Zhu Y F), 何玉凤(He Y F), 李岩(Li Y), 毛崇武(Mao C W), 何乃普(He N P). 化学进展(Prog. Chem. ), 2010, 22: 1952-1963
[18] Clark LC, Gollan F. Science, 1966, 152(730): 1755-1756
[19] Geyer R, Monroe R, Taylor K. Fed. Proc., 1968. 27: 384
[20] Ohyanagi H, Toshima K, Sekita M, Okamoto M, Itoh T, Mitsuno T. Clin. Ther., 1979, 2: 306-312
[21] Maevsky E I, Ivanitsky G R, Makarov K N, Arkhipov V V, Ivashina A I, Kulakova G M, Moroz V V, Pushkin S J, Senina R Y, Starovoitova L N. US 6562872, 2003
[22] Maevsky E I, Ivanitsky H R, Islamov S B, Moroz V V, Bogdanova L A, Karmen N B, Pushkin S Y, Maslennikov I A. Blood Substitutes (ed. Winslow RM). London: Academic Press, 2006. 289-295
[23] Maevsky E I, Axenova O G, Moroz V V, Senina R, Pushkin S, Ivanitsky G. Vestnik Sluzhby Krovi Russ, 2001, 4: 23-29
[24] Keipert P E. Blood Subtitutes(ed. Winslow RM). London: Academic Press, 2006. 312- 321
[25] Riess J G. Vox. Sang., 1991, 61(4): 225-239
[26] Keipert P E. Art. Cells Blood Subs. Immob Biotechnol., 1995, 23: 381- 394
[27] 郑志风(Zheng Z F), 徐宏(Xu H), 董岩(Dong Y), 古宏晨(Gu H C). 化学世界(Chemistry Word), 2001, 42(8): 43-45
[28] Bauer J, Zahres M, Zellermann A, Kirsch M, Petrat F, de Groot H, Mayer C. J. Microencapsul., 2010, 27(2): 122-132
[29] Thomas T G. NY Med. J., 1878, 27: 449-465
[30] Moldovan J. Dtsch. Med. Wochenschr., 1910, 2: 2422-2425
[31] Amberson W R, Mulder A G, Steggerda F R, Flexner J, Pankratz D S. Science, 1933, 78(2014): 106-107
[32] 万英(Wan Y), 周剑涛(Zhou J T). 中国生化药物杂志(Chinese Journal of Biochemical Pharmaceutics), 2004, 25(3): 178- 180
[33] Chatterjee R, Welty E V, Walder R Y, Pruitt S L, Rogers P H, Arnone A, Walder J A. J. Biol. Chem., 1986, 261(21): 9929-9937.
[34] Kobayashi K, Tsuchida E, Horinouchi H. Artificial Oxygen Carrier. Tokoy: Springer, 2005. 38-49
[35] Bunn H F, Jandl J H. Trans. Assoc. Am. Physicians, 1968, 81: 147-152
[36] 路秀玲(Lu X L), 郑春杨(Zheng C Y), 徐宇红(Xu Y H), 苏志国(Su Z G). 中国科学(生命科学)(Science in China (Life Sciences)), 2004, 34(4): 350-359
[37] Winslow R M (Ed). Blood Substitutes. London: Academic Press, 2006, 386-398
[38] Bonsen P, Laver M B, Morris K C. US 4001200, 1975
[39] Humphries R G, Killingback P G, Mann J, Sempik J, Wilson J. Br. J. Pharmacol., 1981, 74: 266
[40] Scholer M, Frietsch T, Jambor C, Knels R. Dtsch. Med. Wochenschr., 2010, 135(12): 575-581
[41] Nolte D, Steinhauser P, Pickelmann S, Berger S, Hrtl R, Messmer K. J. Lab. Clin. Med., 1997, 130(3): 328-338
[42] Thompson A, McGarry A E, Valeri C R, Liberthal W. J. Appl. Physiol., 1994, 77(5): 2348-2354
[43] Johnson J L, Moore E E, Offner P J, Haenel J B, Hides G A, Tamura D Y. Am. J. Surg., 1998, 176(6): 612-617
[44] Gould S A, Sehgal L R, Sehgal H L, Moss G S. Transfusion Science, 1995, 16(1): 5-17
[45] Zheng C Y, Bi J X, Ma G H, Su Z G. Artificial Cells, Blood Substitutes and Biotechnology, 2007, 35: 568-584
[46] Vandegriff K, Bellelli A, Samaja M, Malavalli A, Brunori M, Winslow R M. FASEB J., 2003, 17: A183-A183
[47] Vandegriff K D, Malavalli A, Wooldridge J, Lohman J, Winslow R M. Transfusion, 2003, 43(4): 509-516
[48] Lui F E, Kluger R. Biochemistry, 2009, 48(50): 11912-11919
[49] De Figueiredo L F, Mathru M, Solanki D, Macdonald V W, Hess J, Kramer G C. J. Trauma., 1997, 42(5): 847-854
[50] Burhop K, Gordon D, Estep T. Artif. Cells Blood Substit. Immobil. Biotechnol., 2004, 32(3): 353-374
[51] Natanson C, Kern S J, Lurie P, Banks S M, Wolfe S M. JAMA, 2008, 299(19): 2304-2312
[52] 王昕(Wang X), 赵树铭(Zhao S M). 国际检验医学杂志(International Journal of Laboratory Medicine)2008, 29(5): 418-420
[53] Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E. Artificial Organs, 2009, 33(2): 139-145
[54] Rudolph A S, Klipper R W, Goins B, Phillips W T. Proc. Natl. Acad. Sci. USA, 1991, 88(23): 10976-10980
[55] 赵健(Zhao J), 单晓茜(Shan X Q), 盛燕(Sheng Y), 吴凡(Wu F), 袁媛(Yuan Y), 刘昌胜(Liu C S). 生物医学工程学杂志(J. Biomed. Eng.), 2008, 25(3): 584-588
[56] Kobayashi K, Tsuchida E, Horinouchi H. Artificial Oxygen Carrier, Tokyo: Springer, 2005, 135-160
[57] Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E. J. Intern. Med., 2008, 263(1): 4-15
[58] Pape A, Kertscho H, Meier J, Horn O, Laout M, Steche M, Lossen M, Theisen A, Zwissler B, Habler O. Intensive Care Med., 2008, 34(8): 1534-1543
[59] Abe H, Azuma H, Yamaguchi M, Fujihara M, Ikeda H, Sakai H, Takeoka S, Tsuchida E. Artif. Cells Blood Substit. Immobil. Biotechnol., 2007, 35(2): 157-172
[60] Sakai H, Tomiyama KI, Sou K, Takeoka S, Tsuchida E. Bioconjug. Chem., 2000, 11(3): 425-432
[61] Sakai H, Hara H, Yuasa M, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M. Am J. Physiol. Heart. Circ. Physiol., 2000, 279(3): H908-H915
[62] Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E. Adv. Exp. Med. Biol., 2010, 662: 433-438
[63] Izumi Y, Sakai H, Kose T, Hamada K, Takeoka S, Yoshizu A, Horinouchi H, Kato R, Nishide H, Tsuchida E, Kobayashi K. ASAIO J., 1997, 43(4): 289-297
[64] Linberg R, Conover C D, Shum K L, Shorr R G. In Vivo, 1998, 12(2): 167-173
[65] Plock J A, Tromp A E, Contaldo C, Spanholtz T, Sinovcic D, Sakai H, Tsuchida E, Leunig M, Banic A, Erni D. Crit. Care Med., 2007, 35(3): 899- 905
[66] Horinouchi H, Sakai H, Izumi Y, Kohno M, Tsuchida E, Kobayashi K. ISBT Science Series, 2009, 4: 409-410
[67] Looker D, Abbott-Brown D, Cozart P, Durfee S, Hoffman S, Mathews A J, Miller-Roehrich J, Shoemaker S, Trimble S, Fermi G, Komiyama N H, Nagai K, Stetler G L. Nature, 1992, 356: 258-260
[68] Kobayashi K, Tsuchida E, Horinouchi H. Artificial Oxygen Carrier. Tokyo: Springer, 2005, 127-134
[69] Chang T M. Wiley Interdiscip Rev. Nanomed Nanobiotechnol., 2010, 2(4): 418-430
[70] Chauvierre C, Manchanda R, Labarre D, Vauthier C, Marden M C, Leclerc L. Biomaterials, 2010, 31(23): 6069-6074
[71] Mot A C, Roman A, Lupan I, Kurtz D M Jr. Silaghi-Dumitrescu R. Protein J. 2010, 29(6): 387-393
[72] Tsuchida E, Nishide H, Ohno H. Artif. Cell. Artif. Organ., 1988, 16(1/3): 313-319.
[73] Collman J P, Gagne R R, Halbert T R, Marchon J C, Reed C A. J. Am. Chem. Soc., 1973, 95(23): 7868-7870
[74] Collman J P. Acc. Chem. Res., 1977, 10: 265-272
[75] Riess J G. Chem. Rev., 2001, 101: 2797-2919
[76] Komatsu T, Matsukawa Y, Tsuchida E. Bioconjugate Chem., 2001, 12(1): 71-75
[77] Cameron J H, Graham S, Harvey B H, Liggat J J, McKee A, Soutar I, Scott E L. React. Funct. Polym., 1998, 36(2): 173-183
[78] Nakagawa A, Komatsu T, Iizuka M, Tsuchida E. Bioconjugate Chem., 2008, 19(3): 581-584
[79] Tsuchida E, Sou K, Nakagawa A, Sakai H, Komatsu T, Kobayashi K. Bioconjugate Chem., 2009, 20 (8): 1419-1440
[80] Tsuchida E, Komatsu T, Hamamatsu K, Matsukawa Y, Tajima A, Yoshizu A, Izumi Y, Kobayashi K. Bioconjugate Chem., 2000, 11(1): 46-50
[81] Komatsu T, Hamamatsu K, Tsuchida E. Macromolecules, 1999, 32(25): 8388-8391
[82] Huang Y, Komatsua T, Yamamoto H, Horinouchi H, Kobayashi K, Tsuchida E. Biomaterials, 2006, 27(25): 4477-4483
[83] Wang R M, Komatsu T, Nakagawa A, Tsuchida E. Bioconjugate Chem., 2005, 16(1) : 23-26
[84] Komatsu T, Ishihara S, Tsuchida E, Nishide H, Morokuma C, Nakamura S. Biomacromolecules, 2005, 6(3): 1489-1494
[85] Kano K, Kitagishi H, Kodera M, Hirota S. Angew. Chem. Int. Ed., 2005, 44: 435-438
[86] Kano K, Kitagishi H, Dagallier C, Kodera M, Matsuo T, Hayashi T, Hisaeda Y, Hirota S. Inorg. Chem., 2006, 45(11): 4448-4460
[87] Kano K, Kitagishi H, Mabuchi T, Kodera M, Hirota S. Chem. Asian J., 2006, 1(3): 358-366
[88] Kano K, Kitagishi H, Tanaka S. J. Incl. Phenom. Macro. Chem., 2006, 56: 69-74
[89] Chen J Y, Scerbo M, Kramer G. Clinics, 2009, 64(8): 803-813
[90] Lok C. Nature, 2001, 410(15): 855
[91] Cabrales P. J. Am. Coll. Surg., 2010, 210(3): 271-279
[92] Donahue L L, Shapira I, Shander A, Kolitz J, Allen S, Greenburg G. Transfusion. 2010, 50(7): 1561-1567
[93] Squires J E. Science, 2002, 295(5557): 1002-1005
[94] Pierre L. . http: //biomed. brown. edu/Courses/BI108/2006- 108websites/group09artificialblood/index. htm
[95] Verdu E F, Bercik P, Huang X X, Lu J, Al-Mutawaly N, Sakai H, Tompkins T A, Croitoru K, Tsuchida E, Perdue M, Collins S M. Am. J. Physiol. Gastrointest Liver Physiol., 2008, 295(4): G664-G670
[96] Yamagishi T, Bessho M, Hama M, Katoh R, Yanagida S, Kusuhara M, Ohsuzu F. Artif. Blood, 2007, 14(3): 92-97
[97] Wu W, Li T, Liu J, Yang C. Artif. Cells Blood Substit. Immobil. Biotechnol., 2011, 39(1): 3-6
[98] Lanza G M, Winter P M, Caruthers S D, Hughes M S, Hu G, Schmieder A H, Wickline S A. Angiogenesis, 2010, 13(2): 189-202
[99] Mahon R T, Watanabe T T, Wilson M C, Auker C R. Aviat. Space Environ. Med., 2010, 81(6): 555-559
[100] Zhang Z, He R, Yan K, Guo Q N, Lu Y G, Wang X X, Lei H, Li Z Y. Bioorg. Med. Chem. Lett., 2009, 19(23): 6675-6678

[1] . Structures and Functions of Metalloporphyrin Protein Conjugates [J]. Progress in Chemistry, 2010, 22(10): 1952-1963.
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Artificial Oxygen Carriers