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Progress in Chemistry 2011, Vol. 23 Issue (5): 914-922 Previous Articles   Next Articles

• Review •

Cyclodextrins/Polymer Based (Pseudo)Polyrotaxanes for Biomedical Applications

Dong Haiqing1, Li Yongyong1, Li Lan1, Shi Donglu1,2   

  1. 1. The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai 20009;
    2. Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati, Ohio 45229, USA
  • Received: Revised: Online: Published:
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Cyclodextrin(CD) and its derivatives have the special molecular structures with hydrophobic cavities and hydrophilic surfaces, which can form inclusion complexes with many guest molecules. Construction of biomaterials with stability, structural controllability as well as potential applications by supramolecular self-assembly is one of the research focuses in materials and medical fields. This paper introduces the concept of CDs based (pseudo) polyrotaxanes and the driving forces for their self-assembly, mainly reviews the biomedical applications of (pseudo) polyrotaxanes self-assembled from CDs and polymers, including drug carriers (such as supramolecular hydrogels, supramolecular micelles, supramolecular nanocapsules, drug conjugated (pseudo) polyrotaxane and stimuli-responsive (pseudo) polyrotaxane), gene carriers, multifold recognition and targeting, as well as other applications involving shape memory materials, anticoagulant materials, DNA-cleavage reagent and trypsin inhibitor.

Key words: cyclodextrins, (pseudo)polyrotaxane, biomedical application, self-assembly

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