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• Review •

Preparation and Potential Application of Polymeric Micelles via RAFT Polymerization

Yang Zhenglong, Zhou Dan, Chen Qiuyun   

  1. School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, Tongji University, Shanghai 200092, China
  • Received: Revised: Online: Published:
  • Contact: YANG Zheng-long E-mail:yangzhenglong@tongji.edu.cn
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The rapid progress of polymeric micelles, which due to their attractive advantages such as excellent tissue permeability, compatibilization effect, structural diversity and thermal stability, has raised interest in recent years. In this review, the research progress of amphiphilic block copolymer micelles with special structure and special properties is discussed. The formation mechanism and advantage of polymeric micelles via RAFT polymerization method are introduced. Different thermo- and pH-responsive micelles can be prepared quickly and easily in aqueous solution via RAFT polymerization method. However, dilution effect of polymer micelles greatly affect its practical application when the concentration of the polymer micelle below its critical micelle concentration. To improve the stability of polymer micelles, several methods to prepare polymeric cross-linked micelles are summarized. Finally, the current challenges for the polymeric micelles potential applications in controlled drug release, targeting, biological imaging, catalyst immobilization and other areas are highlighted.

Contents
1 Introduction
2 The RAFT polymerization mechanism
3 Methods to prepare polymeric cross-linked micelles
4 Potential applications of polymeric micelles
4.1 Polymeric micelles for controlled drug release
4.2 Polymeric micelles for drug targeting
4.3 Polymeric micelles for biological imaging
4.4 Polymeric micelles for catalyst immobilization and other area
5 Summary and outlook

Key words: RAFT polymerization, shell cross-linked, polymeric micelles, stability, potential application

CLC Number: 

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