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Progress in Chemistry 2011, Vol. 23 Issue (10): 2160-2168 Previous Articles   Next Articles

• Review •

Modulating the Differentiation of BMSCs by Surface Properties of Biomaterials

Wang Wei, Li Bo, Gao Changyou*   

  1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  • Received: Revised: Online: Published:
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Tissue engineering and regenerative medicine uses seed cells and biodegradable scaffolds to realize tissue regeneration. Interactions between the cells, especially the stem cells, biomaterials take a pivotal factor in regulating structures and functions of the regenerated tissues. Recent focus has been moving to bone marrow mesenchymal stem cells (BMSCs) in terms of biomedical applications because of their ease of isolation and expansion, multipotency and low immunogenicity. However, in order to better utilize their therapeutic potentials it is extremely important to stimulate the desired differentiation while avoid undesired differentiation. The differentiation of BMSCs is regulated by the cell microenvironment or niche. Meanwhile, the biomaterials acted as the carriers or scaffolds of BMSCs with different properties will have a great impact on their differentiation, and in some cases control the fate of BMSCs. The surface charge, hydrophilicity and hydrophobicity as well as surface morphology have an ability to define the differentiation of BMSCs to osteoblasts or chondrocytes. A surface coating or grafting technique is employed to promote the differentiation of BMSCs to targeted cells. More recent results show that the differentiation of BMSCs is also induced by viscoelasticity and geometry of the biomaterials. This article reviews the recent progress in BMSCs differentiation governed by different properties of biomaterials, which may provide a reference to design the scaffolds for accommodation and applications of BMSCs in regenerative medicine.

Contents
1 Introduction
2 Modulating the differentiation of BMSCs by biomaterials' properties
2.1 Influence of surface charge of biomaterials on the differentiation of BMSCs
2.2 Influence of surface wettability of biomaterials on the differentiation of BMSCs
2.3 Influence of functional groups and surface coating of biomaterials on the differentiation of BMSCs
2.4 Influence of peptides in biomaterials on the differentiation of BMSCs
2.5 Influence of biomaterials elasticity on the differentiation of BMSCs
2.6 Influence of biomaterials' morphology on the differentiation of BMSCs
3 Conclusion and perspectives

Key words: biomaterials, surfaces and interfaces, regenerative medicine, BMSCs, differentiation

CLC Number: 

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