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Progress in Chemistry 2011, Vol. 23 Issue (10): 2119-2131 Previous Articles   Next Articles

• Review •

Applications of G-Quadruplex-Hemin DNAzymes in Sensor Design

Kong Deming*   

  1. Research Centre for Analytical Sciences, Department of Chemistry, Nankai University, Tianjin 300071, China
  • Received: Revised: Online: Published:
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G-quadruplex-Hemin DNAzymes are a kind of peroxidase-like artificial enzymes formed by nucleic acid G-quadruplexes and Hemin. As an kind of important DNAzymes, G-quadruplex-hemin DNAzymes have attracted more and more attention in analytical chemistry in these years. G-quadruplex-hemin DNAzymes have been used in the design of several sensors, such as metal ion sensors, aptasensors, enzyme sensors, DNA sensors and drug sensors. This paper provides an overview of the progress of G-quadruplex-hemin DNAzyme-based sensors and the design strategies are introduced in detail. In addition, the future development of this kind of DNAzymes is prospected.

Contents
1 Introduction
2 Metal ion sensors
2.1 K+ sensors
2.2 Hg2+ sensors
2.3 Ag+ sensors
2.4 Pb2+ sensors
2.5 Cu2+ sensors
3 Aptasensors
4 Enzyme sensors
4.1 Telomerase sensors
4.2 Methyltransferase sensors
5 DNA sensors
5.1 Homogenous DNA sensors
5.2 Heterogenous DNA sensors
6 Drug sensors
7 Prospect

Key words: DNAzyme, G-quadruplex, hemin, sensors, peroxidase

CLC Number: 

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