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Progress in Chemistry 2011, Vol. 23 Issue (01): 231-245 Previous Articles   Next Articles

• Review •

Preparation,Application and Functionalization of Hydroxyapatite Microspheres

Ni Songbo1, Li Yanbao1, Wang Xiumei2   

  1. 1. State Key Laboratory of Materials-Oriented Chemical Engineering, College of Materials Science and Engineering, Nanjing University of Technology, Nanjing 210009, China;
    2. Shenyang Sinqi Phamaceutical Co., Ltd., Shengyang 110024, China
  • Received: Revised: Online: Published:
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Hydroxyapatite (HA) is a main mineral in vertebrate bone.During the latest years,HA has attracted attention from researchers in the areas of biology,medicine and materials,due to its special surface characteristics,physical and chemical properties,and excellent biocompatibility,bioactivity and osteoconductivity.In this review,the different methods used to prepare HA microspheres,including spray,template,microemulsion,emulsion technique and other methods are described in detail.The advantage and disadvantage of these methods are summarized.The pore sizes and surface areas of microspheres prepared in different ways are also listed.Subsequently,since HA microspheres possess high mobility,specific surface area and strength,low aggregation ability,injectability and light mass,they have been applied as carriers,scaffolds in tissue engineering,environmental protection,fillers and chromatography.Finally,three strategies are proposed to functionalize HA microspheres,which are surface treatment/modification,doping and dispersing HA in other matrix,respectively.HA microspheres have significantly potential to be applied as carriers,protein separation and cell scaffold in the future.

Key words: hydroxyapatite(HA), microsphere, carrier, functionalization

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[1] 沈卫(Shen W), 顾燕茅(Gu Y M), 刘昌胜(Liu C S), 孙祥明(Sun X M), 胡黎明(Hu L M). 硅酸盐通报(Bulletin of the Chinese Ceramic Society), 1996, (1): 45—51
[2] Suchanek W, Yoshimura M. J. Mater. Res., 1998, 13(1): 94—117
[3] 李延报(Li Y B), 李东旭(Li D X), 翁文剑(Weng W J). 无机材料学报(Journal of Inorganic Materials), 2007, 22(5): 783—790
[4] 傅宪辉(Fu X H), 沈志刚(Shen Z G). 力学与实践(Mechanics in Engineering), 2005, 27(2): 7—13
[5] Mizushima Y, Ikoma T, Tanaka J, et al. J. Control. Release, 2006, 110(2): 260—265
[6] Sun R X, Lu Y P, Chen K Z. Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 2009, 29(4): 1088—1092
[7] Cho J S, Ko Y N, Koo H Y, et al. J. Mater. Sci.-Mater. Med., 2010, 21(4): 1143—1149
[8] Cho J S, Kang Y C. J. Alloy. Compd., 2008, 464(1/2): 282—287
[9] Trommer R M, Santos L A, Bergmann C P. Mater. Sci. Eng. C-Mater. Biol. Appl., 2009, 29(6): 1770—1775
[10] Weng J, Wang M, Chen J Y. Biomaterials, 2002, 23(13): 2623—2629
[11] Sun R X, Lu Y P, Li M S, et al. Surf. Coat. Technol., 2005, 190(2/3): 281—286
[12] Hutchens S A, Benson R S, Evans B R, et al. Biomaterials, 2006, 27(26): 4661—4670
[13] Klinkaewnarong J, Swatsitang E, Masingboon C, et al. Curr. Appl. Phys., 2010, 10(2): 521—525
[14] Wang Y S, Hassan M S, Gunawan P, et al. J. Colloid Interface Sci., 2009, 339(1): 69—77
[15] Wang P, Yook S W, Jun S H, et al. Mater. Lett., 2009, 63(13/14): 1207—1209
[16] Qiu C F, Xiao X F, Liu R F. Ceram. Int., 2008, 34(7): 1747—1751
[17] Zhao Y F, Ma J. Microporous Mesoporous Mater., 2005, 87(2): 110—117
[18] Ye F, Guo H, Zhang H, et al. Acta Biomater., 2010, 6(6): 2212—2218
[19] He Q J, Huang Z L, Liu Y, et al. Mater. Lett., 2007, 61(1): 141—143
[20] Ganesan K, Epple M. New J. Chem., 2008, 32(8): 1326—1330
[21] Xiao X F, Liu R F, Qiu C F, et al. Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 2009, 29(3): 785—790
[22] Zhang H G, Zhu Q S, Wang Y. Chem. Mater., 2005, 17(23): 5824—5830
[23] Schmidt S M, Moran K A, Kent A M T, et al. J. Biomed. Mater. Res. Part A, 2008, 87A(2): 418—428
[24] Schmidt H T, Gray B L, Wingert P A, et al. Chem. Mater., 2004, 16(24): 4942—4947
[25] Guo Y P, Zhou Y, Jia D C, et al. Microporous Mesoporous Mater., 2009, 118(1/3): 480—488
[26] Guo Y P, Lin T S, Zhou Y, et al. Microporous Mesoporous Mater., 2010, 127(3): 245—249
[27] Ma M Y, Zhu Y J, Li L, et al. J. Mater. Chem., 2008, 18(23): 2722—2727
[28] Yao A H, Ai F R, Liu X, et al. Mater. Res. Bull., 2010, 45(1): 25—28
[29] Wang Q, Huang W H, Wang D P, et al. J. Mater. Sci.-Mater. Med., 2006, 17(7): 641—646
[30] Zhang H B, Zhou K C, Li Z Y, et al. Biomed. Mater., 2009, 4(3):
[31] Kawai T, Sekikawa H, Unuma H. J. Ceram. Soc. Jpn., 2009, 117(1363): 340—343
[32] Ethirajan A, Ziener U, Landfester K. Chem. Mater., 2009, 21(11): 2218—2225
[33] Ethirajan A, Ziener U, Chuvilin A, et al. Adv. Funct. Mater., 2008, 18(15): 2221—2227
[34] Shchukin D G, Sukhorukov G B, Mohwald H. Chem. Mater., 2003, 15(20): 3947—3950
[35] Cheng X K, Huang Z L, Li J Q, et al. Cryst. Growth Des., 2010, 10(3): 1180—1188
[36] 任卫(Ren W), 李世普(Li S P), 王友法(Wang Y F), 曹献英(Cao X Y), 陈晓明(Chen X M). 硅酸盐通报(Bulletin of the Chinese Ceramic Society), 2006, 6: 27—30
[37] 任卫(Ren W), 李世普(Li S P), 王友法(Wang Y F). 材料研究学报(Chinese Journal of Materials Research), 2004, 18(3): 257—264
[38] Kimura I, Honma T, Riman R E, J. Ceram. Soc. Jpn., 2007, 115(1348): 888—893
[39] Park J S, Hong S J, Kim H Y, et al. Tissue Eng. Part A, ２０１０,16(5): 1681—1691
[40] Pradeesh T S, Sunny M C, Varma H K, et al. Bull. Mater. Sci., 2005, 28(5): 383—390
[41] Takai C, Hotta T, Shiozaki S, et al. Chem. Commun., 2009, 5533—5535
[42] Jevtic M, Radulovic A, Ignjatovic N, et al. Acta Biomater., 2009, 5(1): 208—218
[43] Cai Y R, Pan H H, Xu X R, et al. Chem. Mater., 2007, 19(13): 3081—3083
[44] Kandori K, Noguchi Y, Fukusumi M, et al. J. Phys. Chem. C, 2010, 114(14): 6440—6445
[45] Xie M, Oldery M , Andreassen J P, et al. Acta Biomater., 2010, 6(9): 3665—3675
[46] Nassif N, Martineau F, Syzgantseva O, et al. Chem. Mater., 2010, 22(12): 3653—3663
[47] Ribeiro C C, Barrias C C, Barbosa M A. Biomaterials, 2004, 25(18): 4363—4373
[48] Ma'mani L, Heydari A, Shiroodi R K. Curr. Org. Chem., 2009, 13(7): 758—762
[49] Boonsongrit Y, Abe H, Sato K, et al. Mater. Sci. Eng. B-Adv. Funct. Solid-State Mater., 2008, 148(1/3): 162—165
[50] Wang Y J, Wang X D, Wei K, et al. Mater. Lett., 2007, 61(4/5): 1071—1076
[51] Huang W, Wang Y J, Ren L, et al. Mater. Sci. Eng. C-Mater. Biol. Appl., 2009, 29(7): 2221—2225
[52] 王旭东(Wang X D), 王迎军(Wang Y J), 魏坤(Wei K), 赵娜如(Zhao N R), 张淑花(Zhang S H). 硅酸盐学报(Journal of the Chinese Ceramic Society), 2008(09): 1225—1230
[53] Wang S, Wang X, Xu H, et al. Adv. Powder Technol., 2010, 21(3): 268—272
[54] Sivakumar M, Rao K P. J. Biomed. Mater. Res. Part A, 2003, 65A(2): 222—228
[55] Sivakumar M, Rao K P. Biomaterials, 2002, 23(15): 3175—3181
[56] Zhu X D, Zhang H J, Fan H S, et al. Acta Biomater., 2010, 6(4): 1536—1541
[57] Zhu X D, Fan H S, Xiao Y M, et al. Acta Biomater., 2009, 5(4): 1311—1318
[58] Ferraz M P, Mateus A Y, Sousa J C, et al. J. Biomed. Mater. Res. Part A, 2007, 81A(4): 994—1004
[59] Tomoda K, Ariizumi H, Nakaji T, et al. Colloid Surf. B-Biointerfaces, 2010, 76(1): 226—235
[60] Ho M L, Fu Y C, Wang G J, et al. J. Control. Release, 2008, 128(2): 142—148
[61] Santoni B G, Pluhar G E, Motta T, et al. Bio-Med. Mater. Eng., 2007, 17(5): 277—289
[62] 石海涛(Shi H T), 张志荣(Zhang Z R), 龚涛(Gong T). 华西药学杂志(West China Journal of Pharmaceutical Sciences ), 2008(01): 22—25
[63] Paul W, Nesamony J, Sharma C P. J. Biomed. Mater. Res., 2002, 61(4): 660—662
[64] Shi P J, Zuo Y, Li X W, et al. J. Biomed. Mater. Res. Part A, 2010, 93A(3): 1020—1031
[65] Emoto M, Naganuma Y, Choijamts B, et al. Cancer Sci., 2010, 101(4): 984—990
[66] Lv Q, Nair L, Laurencin C T. J. Biomed. Mater. Res. Part A, 2009, 91A(3): 679—691
[67] Peng Q, Jiang F X, Huang P, et al. J. Biomed. Mater. Res. Part A, 2010, 93A(3): 920—929
[68] Nukavarapu S P, Kumbar S G, Brown J L, et al. Biomacromolecules, 2008, 9(7): 1818—1825
[69] Mateus A Y P, Barrias C C, Ribeiro C, et al. J. Biomed. Mater. Res. Part A, 2008, 86A(2): 483—493
[70] Inanc B, Elcin A E, Koc A, et al. J. Biomed. Mater. Res. Part A, 2007, 82A(4): 917—926
[71] Oliveira S M, Barrias C C, Almeida I F, et al. J. Biomed. Mater. Res. Part B, 2008, 87B(1): 49—58
[72] Shen H, Hu X X, Yang F, et al. Acta Biomater., 2010, 6(2): 455—465
[73] Akman A C, Tigh R S, Gumusderelioglu M, et al. J. Biomed. Mater. Res. Part A, 2010, 92A(3): 953—962
[74] Ridenour B, Kontis T C. Facial Plast. Surg., 2009, 25(2): 100—105
[75] 叶桂生(Ye G S). 硅酸盐通报(Bulletin of the Chinese Ceramic Society), 2006, 25(5): 143—146
[76] Cummings L J, Snyder M A, Brisack K. Protein chromatography on hydroxyapatite columns, in Guide to Protein Purification, Second Edition. 2009. 387—404
[77] 王爱娟(Wang A J), 吕宇鹏(Lv Y P), 孙瑞雪(Sun R X). 材料导报(Materials Review), 2006, 20(60): 111—114
[78] Han X, Du M, Ma Y F, et al. J. Mater. Sci., 2008, 43(16): 5618—5625
[79] Paul W, Sharma C P. J. Colloid Interface Sci., 1995, 174(1): 224—229
[80] Akazawa T, Kobayashi M, Yoshida M, et al. J. Chromatogr. A, 1999, 862(2): 217—220
[81] 王永峰(Wang Y F), 靳安民(Jin A M), 魏坤(Wei K), 王旭东(Wang X D), 汤善华(Tang S H), 闵少雄(Min S X). 南方医科大学学报(Journal of Southern Medical University), 2006, 26(6): 754—756
[82] Lepretre S, Chai F, Hornez J C, et al. Biomaterials, 2009, 30(30): 6086—6093
[83] Teng S H, Lee E J, Wang P, et al. J. Biomed. Mater. Res. Part B, 2009, 90B(1): 275—282
[84] Balasundaram G, Sato M, Webster T J. Biomaterials, 2006, 27(14): 2798—2805
[85] Liu J K, Yang X H, Tian X G. Powder Technol., 2008, 184(1): 21—24
[86] Hou C H, Hou S M, Hsueh Y S, et al. Biomaterials, 2009, 30(23/24): 3956—3960
[87] Liu J K, Wu Q S, Ding Y P. Eur. J. Inorg. Chem., 2005(20): 4145—4149
[88] Doat A, Fanjul M, Pelle F, et al. Biomaterials, 2003, 24(19): 3365—3371
[89] Shin U S, Park J H, Hong S J, et al. Mater. Lett., 2010, 64(20): 2261—2264
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