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Progress in Chemistry 2011, Vol. 23 Issue (01): 221-230 Previous Articles   Next Articles

• Review •

Microfluidic Chip Based Microarray Analysis

Qu Xiangmeng1,2, Lin Rongsheng3, Chen Hong1,2   

  1. 1. Pen-Tung Sah Micro-Nano Technology Research Center, Xiamen University, Xiamen 361005, China;
    2. Department of Mechanical and Electrical Engineering, Xiamen University, Xiamen 361005, China;
    3. Food and Drug Course Teaching Department, Xiamen Huaxia Vocational College, Xiamen 361024, China
  • Received: Revised: Online: Published:
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Microarray chip has been widely used in many fields because of its high throughput,miniaturization and automation.But there are still some disadvantages,such as highly priced instruments,long analysis time,low sensitivity and lacking of parallel analysis ability.Microfluidic device has large specific surface area and short diffusion distance because of its micrometer scale size,which can provide faster hybridization,higher detection efficiency,better analysis performance,and lots of parallel channels can be fabricated for multiple sample analysis.In present,the combination of microfluidic chip and microarray chip has been widely reported,specific hybridization method has been developed and the advantages have been demonstrated experimentally and theoretically.This review presents the research advances of microfluidic chip based microarray analysis,mainly including the specific hybridization procedures,improvement measures and mathematical modeling of hybridization.The progress in other steps has also been introduced.In addition,the disadvantages and advantages by combining microfluidic and microarray technologies are discussed.

Key words: microfluidic chip, microarray chip, nucleic acid, hybridization

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