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Progress in Chemistry 2011, Vol. 23 Issue (01): 213-220 Previous Articles   Next Articles

• Review •

Sheddable Nanoparticles for Biomedical Application

Ren Tianbin, Feng Yue, Dong Haiqing, Li Lan, Li Yongyong   

  1. School of Material Science and Engineering, The Institute for Advanced Materials & Nano Biomedicine, Tongji University, Shanghai 200092, China
  • Received: Revised: Online: Published:
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The development of new intelligent drug carrier is one of the most critical challenges in cancer treatment.Nano-vehicles such as liposomes,polymeric micelles and lipoplexes are extensively investigated for this purpose.For successful drug delivery,one prerequisite is the long circulating time in vivo.Nanoparticles which used hydrophilic polymers as the “stealth” coating materials can prolong the circulating time via preventing the vehicles from the clearance by blood proteins and being uptaken by macrophages.However,hydrophilic coatings of nanoparticles may hamper the drug release and interaction with target cell after localizing at the pathological site,limiting the therapeutic effect.Presently,this dilemma could be circumvented by the development of the sheddable nanoparticles.Sheddable nanoparticles,which are capable of shedding their “outer layers” when needed,may facilitate the drug release as well as the interaction with the target cell.Herein,we present an overview of the recent work on sheddable nanoparticles with different “shedding” mechanisms,including pH-sensitivity,redox sensitivity and enzyme digestion,with an emphasis on their designs and biomedical applications.In addition,recent advances and perspectives of the sheddable nanoparticles are included.

Key words: sheddable, nanoparticles, drug carrier

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