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Progress in Chemistry 2010, Vol. 22 Issue (11): 2126-2133 Previous Articles   Next Articles

• Review •

New Advances of Knoevenagel Reaction Assisted with Physical Technologies

Yang Kai  Wang Zhaoyang**  Fu Jianhua  Tan Yuehe   

  1. (School of Chemistry and Environment, South China Normal University, Guangzhou 510006,China)
  • Received: Revised: Online: Published:
  • Contact: Wang Zhaoyang E-mail:wangwangzhaoyang@tom.com;wangzy@scnu.edu.cn
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The by-product of Knoevenagel reaction is water, and the synthetic methods assisted with physical technologies, such as microwave (MW), ultrasound (US) and grinding have many advantages including high efficiency, saving energy, and environmental friendliness, both make the Knoevenagel reaction assisted with physical technologies meet the request of green chemistry very much. Now, Knoevenagel reaction has been widely used in organic synthesis, and the emergence of a variety of physical assistive technologies has increasingly important effects on Knoevenagel reaction, especially in the fields of increasing the reaction yield, simplifying the experimental operation, and expanding its application scope. At the same time, the importance has been attached to the exploration on the industrialization of Knoevenagel reaction via grinding. Based on the classification of different physical assistive technologies, such as MW, US and grinding, the recent progress in Knoevenagel reaction, especially the new application of Knoevenagel reaction in the synthesis of multi-heterocyclic compounds via multi-component reactions (MCR) or tandem reaction including in Knoevenagel reaction has been reviewed. In the future, in order to make Knoevenagel reaction more environmentally friendly, both synthetic methodology research and industrialization research of Knoevenagel reaction based on the above physical assistive technologies are noteworthy in the research on Knoevenagel reaction.

Contents
1 Introduction
2 Knoevenagel reaction assisted with microwave
3 Knoevenagel reaction assisted with ultrasound
4 Knoevenagel reaction assisted with grinding
5 Conclusion

Key words: Knoevenagel reaction, microwave irradiation, ultrasound irradiation, grinding, green chemistry

CLC Number: 

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