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Progress in Chemistry 2010, Vol. 22 Issue (09): 1852-1868 Previous Articles   

• Review •

Structures and Mechanism of Action for Complex Ⅲ Inhibiting-Fungicides

Zhang Lu1  Hou Yuxia1  Yuan Huizhu2  Qin Zhaohai1**   

  1. (1. College of Science, China Agricultural University, Beijing 100193, China;2. Institute of Plant Protection, Chinese Academy of Agriculture Science, Beijing 100193, China)
  • Received: Revised: Online: Published:
  • Contact: Qin Zhaohai E-mail:qinzhaohai@263.com
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Complex III is an essential component for cellular respiration chain and one of the most important targets of fungicides. In recent years, the application of fungicide which uses Complex III as a target has been more and more extensive. In this paper, the advancement of structure and functin of Complex III was summerized first, and then different action mechanisms of various Complex III inhibiting-fungicides, including Qi site inhibitors Antimycin A, Cyazofamid and Surangin B, Qo site inhibitors strobilurins, Famoxadone, Myxothiazol, Stigmatellin and UHDBT, and double sites inhibitor NQNO were reviewed. A detailed structure-activity relationships discussion about these fungicides was also given.

Contents
1 Introduction
1.1 The structure of complex III
1.2 The function of complex III
2 The complex III-targeted inhibitors
2.1 Qi site inhibitors
2.2 Qo site inhibitors
2.3 Both Qi and Qo sites inhibitor
3 Structure-activity relationship
3.1 Qi site inhibitors
3.2 Qo site inhibitors
4 Conclusions and outlook

Key words: Complex III inhibitors, fungicide, action mechanism, structure-activity relationship

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