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Progress in Chemistry 2010, Vol. 22 Issue (09): 1819-1825 Previous Articles   Next Articles

• Review •

Preparation and Application of Core-shell Magnetic Molecularly Imprinted Polymer Microspheres

Yang Weihai1,2   WuYao1   Zhang Yi1   Wei Chen1   Yan Shoulei1**   Wang Qingzhang1   

  1. (1.College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070,China;2.Huangdao Entry-Exit Inspection and Quarantine Bureau,Qingdao 266555,China)
  • Received: Revised: Online: Published:
  • Contact: Yan Shoulei E-mail:yanshoulei1225@sohu.com
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Molecular imprinting technology is a bordine subject newly developed from combined high polymer chemistry, biochemistry, etc. Molecularly imprinted polymer  prepared by molecular imprinting technology   is a new polymer material with many advantages, such as excellent selectivity, high adsorption, high efficiency in chromatography and easy design. It is being increasingly used for several high technology fields, for instance, solid-phase extraction, chromatographic separation, bio- and chemo-sensors, targeted drug delivery, catalysis, immunoassays and artificial enzyme , etc. As a kind of novel functional material, magnetic polymer microspheres developed in recent years have been widely used in the collection or separation of bioactive matter, targeted drug delivery, and disease’s diagnoses or therapy. The core-shell magnetic molecularly imprinted polymer microspheres  prepared by surface molecularly imprinting on magnetic particles have combined the advantages of both molecularly imprinted polymer and magnetic polymer microspheres, especially good superparamagnetic and high selective adsorption. This review focuses on the preparation, structure and properties of core-shell magnetic molecularly imprinted polymer microspheres, as well as their application in chemical analysis, biological separation, and targeted drug delivery in recent years. The problems and challenges that still should be resolved are pointed out and the development tendency in these researches are discussed.

Contents
1 Introduction
2 Structure and characteristics of core-shell magnetic molecularly imprinted polymer microspheres
3 Preparation of core-shell magnetic molecularly imprinted polymer microspheres
3.1 Surface modification of magnetic particles
3.2 Surface molecularly imprinting on magnetic particles
4 Application of core-shell magnetic molecularly imprinted polymer microspheres
4.1 Chemical analysis
4.2 Biological separation
4.3 Targeted drug delivery
5 Outlook

Key words: molecular imprinting, core-shell magnetic molecularly imprinted polymer microspheres, preparations, applications

CLC Number: 

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