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Progress in Chemistry 2010, Vol. 22 Issue (09): 1735-1740 Previous Articles   Next Articles

• Review •

Microcapsules from the Self-Assembly of Nanoparticles at Interfaces

Yang Xiaochao1,2 Mo Zhihong1,2**   

  1. (1. College of Bioengineering, National Key Laboratory for Novel Micro/Nano Device and System Technology,Chongqing University ,Chongqing 400044, China; 2. College of Chemistry and Chemical Engineering,Chongqing University, Chongqing 400044, China)
  • Received: Revised: Online: Published:
  • Contact: Mo Zhihong E-mail:zhihmo@cqu.edu
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Microcapsules are multifunctional materials with applications in various fields related to biomedical research. In the previous studies, lipids and polymers were intensively used as microcapsule shell construction materials. Recently, the self-assembly of nanoparticles at emulsion interfaces have showed great potential as an alternative for microcapsule fabrication. The construction of microcapsule shells using nanoparticles as building blocks incorporated the unique physiochemical properties of nanoparticles into the functional capabilities of the microcapsules. The new properties derived from nanoparticles, such as enhanced mechanical strength, controllable permeability, readily surface modification and controlled release, making the microcapsules of great interest in bio-delivery applications. In this paper, the recent scientific advances in the self-assembly of nanoparticle protected microcapsules including the theories for nanoparticle interfacial assembly, the strategies for the fabrication of stable microcapsule shells, and the reduction of polydispersity of microcapsules were reviewed. The challenges for the self-assembly of nano-sized capsules were discussed and a proposal for the development of nano-sized capsules was concluded.

Contents 
1 Introduction
2 Self-assembly theories for microcapsule shell construction
3 Fabrication of nanoparticle shells
3.1 Cross-linked nanoparticles as microcapsule shell
3.2 Nanoparticle/protein conjugates as microcapsule shell
3.3 Janus nanoparticles as microcapsule shell
4 Reduce the polydispersity of microcapsules
5 Conclusions and Outlook

Key words: nanoparticles, emulsion, self-assembly, microcapsule

CLC Number: 

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