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Progress in Chemistry 2010, Vol. 22 Issue (08): 1665-1671 Previous Articles   Next Articles

• Review •

Effect of Renal Epithelial Cell After Injury on Biomineralization of Calcium Oxalate

 Ouyang Jianming**  Yang  Rue  Tan  Jin   

  1. (Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China)
  • Received: Revised: Online: Published:
  • Contact: Ouyang Jianming E-mail:toyjm@jnu.edu
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Kidney stone is the product of pathologic biomineralization, with calcium oxalate (CaOxa) as the main mineral component. The injury of renal tubular epithelial cell (REC) plays an important role in the formation process of kidney stone. In this paper, it is summarized that the functional molecules expressed on the surface of cellular membrane especially the molecules containing acidic groups and promoting crystal adhesion. These functional molecules includes phosphatidylserine, hyaluronic acid, osteopontin, and transmembrane glycoprotein, etc. The mechanism and influence factors of these functional molecules on regulation of nucleation, growth and adhesion of calcium oxalate were discussed at the molecular and supramolecular level. The research direction is also indicated.

Contents
1 Introduction
2 Expression of function molecules and changes of biochemical index after injury of renal epithelial cell 
2.1 Surface exposure of acidic phospholipids 
2.2 Expression of hyaluronic acid 
2.3 Expression of proteins 
2.4 Change of biochemical indicators 
3 Effect of injured renal epithelial cells on the formation of renal stones 
3.1 Cell injury to promote nucleation and growth of urinary stone mineral 
3.2 Cell injury to promote adherence of CaOxa crystals 
4 Interaction between cells and crystals
5 Influence factors in modulation process of renal epithelial cell on stones 
5.1 pH
5.2 Inhibitors 
6 Outlook

Key words: biomineralization, calcium oxalate, crystal adhesion, kidney stone, Cell modulation

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