Magnetic core-shell mesoporous silica microspheres as a new functional composite materials, has become one of the many areas of research focus. The authors reviewed the recent research of synthesis of mesoporous core-shell magnetic silica microspheres by template. More importantly, the sol - gel process and microemulsion method on solid microspheres and hollow microspheres preparation are mainly discussed. The biomedicine applications of the magnetic mesoporous silica microspheres, such as protein or DNA separation, targeted drug delivery are described. Furthermore, in catalysis field, such as magnetic acid catalysis, hydrogenation catalysis, nano noble-metal catalysis, as well as prospects of its development trend are illustrated.

Contents
1 Introduction
2 Researches of Solid Magnetic Mesoporous Silica Microspheres
2.1 TEOS (Tetraethylorthosilicate) Hydrolysis Method
2.2 Stober method
2.3 Microemulsion Method
3 Researches of Hollow Magnetic Mesoporous Silica Microspheres
3.1TEOS (Tetraethylorthosilicate) Hydrolysis Method
3.2 Stober Method
4 Biomedicine Applications
4.1 Dispersion, Stabilisy of Magnetic Nano-particles
4.2 Size Effect of Magnetic Nano-particle
4.3 Magnetic Nano-particles on Cell Toxicity and its Degradation
4.4 Separation of Protein and DNA
4.5 The Application in the Targeted Drug Delivery Carrier
5 Magnetic Catalysis
5.1 Magnetic Acid Catalysis
5.2 Hydrogenation Catalysis
5.3 Nano Noble-metal Catalysis
5.4 Photochemical Catalysis
6 Conclusions and Outlook