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Progress in Chemistry 2010, Vol. 22 Issue (04): 760-772 Previous Articles   

• Invited Article •

Anticoagulant Biomaterials

He ShuMan; Zhou Jian**   

  1. (School of Chemistry and Chemical Engineering, Guangdong Provincial Key Lab for Green Chemical Product Technology, South China University of Technology, Guangzhou 510640, China)
  • Received: Revised: Online: Published:
  • Contact: Zhou Jian E-mail:jianzhou@scut.edu.cn
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In this paper, the research progress on anticoagulant materials is reviewed. The mechanism of blood clotting and thrombus formation, techniques to improve anticoagulant behavior of biomaterials, characterization methods for anticoagulant biomaterials are discussed. In addition, problems in this field are analyzed and a perspective regarding the molecular design of novel anticoagulant biomaterials is made.

Contents
1 Introduction
2 The formation mechanism and pathways of coagulation
3 The preparation of modified anticoagulant materials
3.1 Physical and chemical modification of material surfaces
3.2 Biological modification of material surfaces to form pseudointima
3.3 Addition of bioactive materials
3.4 Comparison of anticoagulant materials
4 The characterization of anticoagulant materials
4.1 Infrared spectroscopy
4.2 Atomic force microscopy
4.3 X-ray photoelectron spectroscopy
4.4 Scanning electron microscopy
4.5 Surface plasmon resonance
4.6 Quartz crystal microbalance
4.7 Evaluation of characterization techniques
5 Conclusion and prospects

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Abstract

Anticoagulant Biomaterials