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Progress in Chemistry 2010, Vol. 22 Issue (04): 648-653 Previous Articles   Next Articles

• Invited Article •

Applications of Cyclic Peptide Nanotubes

Tang Min; Fan Jianfen*; Liu Jian; He Liangjun; He Ke   

  1. ( College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China)
  • Received: Revised: Online: Published:
  • Contact: Fan Jianfen E-mail:jffan1305@163.com
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Cyclopeptides, adopting β-sheet-like arrangements, can easily stack to form hollow tubular ensembles through the intermolecular hydrogen-bond network. A wide range of multi-structural and functional cyclopeptide nanotubes can be produced by changing the structures and numbers of peptide subunits employed or modifying with variant functional groups. Firstly, the present paper reviews the application progress of the experimental and theoretical researches of self-assembling cyclopeptide nanotubes mimicking biologic transmembrane channels, focusing on the influences of the structures, polarities and hydrophobic properties on the transportation properties and the progress of molecular dynamic (MD) simulations of cyclopeptide nanotubes as water transportation channels. Secondly, the experimental research advances of cyclopeptide nanotubes using as the templets to produce biosensors by synthesis with functional nanomaterials such as electronic, optical and magnetic ones. The following brings forth the potential application foregrounds of cyclopeptide nanotubes functionating as medicines or drug carriers, especially in developing antibacterial and anti-infectional drugs. Finally, the experimental and theoretical research progress of the applications of cyclopeptide nanotubes functionating as the templets to prepare magnetic and electronic nanomaterials is reviewed.

Contents
1 Introduction
2 Applications of cyclic peptide nanotubes
2.1 Transmembrane ion channels
2.2 Biosensors
2.3 Antibacterial and drug-delivery agents
2.4 Megnetic and electronic nanomaterials
3 Outlook

Key words: cyclopeptides nanotubes, transmembrane ion channels, biosensors

CLC Number: 

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Abstract

Applications of Cyclic Peptide Nanotubes