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Progress in Chemistry 2010, Vol. 22 Issue (04): 631-638 Previous Articles   Next Articles

• Invited Article •

Advances in Synthesis and Application of Imidazopyridine Derivatives

Liu Jianchao1; Chen Qiyuan2**   

  1. (1. College of Chemistry , Central China Normal University, Wuhan 430079, China; 2. College of Chemistry and Chemical Engineering, Central South University, Wuhan 410083, China)
  • Received: Revised: Online: Published:
  • Contact: Chen Qiyuan E-mail:journal@mail.ccnu.edu.cn
  • Supported by:

    postdoctor science foundation of china

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Imidazopyridine derivatives are of great importance for their remarkable biological properties. Their structrues are similar to those of indoles and azaindoles, two important heterocycles involved in many alkaloids. Many of them have been demonstrated as inhibitors of the target enzymes and used as medicines, herbicides and fungicides. The imidazopyridines comprise four important isomers: imidazo[4,5-b]pyridine, imidazo[4,5-c]pyridine, imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine. This paper reviews the advances in synthesis and application on imidazopyridines such as imidazo[4,5-b]pyridine and imidazo[4,5-c]pyridine derivatives in recent years.

Contents
1 Introduction
2 Synthesis of imidazo[4,5-b]pyridine
2.1 Synthesized by pyridine derivatives
2.2 Synthesized by imidazole derivatives
3 Synthesis of imidazo[4,5-c]pyridine
3.1 Synthesized by pyridine derivatives
3.2 Synthesized by imidazole derivatives
4 Conclusion

Key words: imidazopyridine derivatives, heterocycles, synthesis

CLC Number: 

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