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Progress in Chemistry 2010, Vol. 22 Issue (04): 603-609 Previous Articles   Next Articles

• Invited Article •

99mTc Labeled Folate Tumor Imaging Agents

Zhang Yadong; Lu Jie**   

  1. ( Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China)
  • Received: Revised: Online: Published:
  • Contact: Lu Jie E-mail:ljie74@bnu.edu.cn
  • Supported by:

    National Natural Science Foundation

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Folate receptor (FR) which is highly expressed on many malignant endothelial cancer cells, is a promising target. Folic acid is an important target-specific delivery molecule with high binding affinity for FR. Therefore the development of 99mTc labeled folate tumor imaging agents has become a hot subject of interest in the radiopharmaceutical field. Different types of 99mTc labeled folate tumor imaging agents and their applications as well as problems in using are summarized in this review. Design methods and the trend for development of this kind of imaging agents are also been discussed.

Contents
1 Introduction
2 General strategy for the design of folate-receptor-targeted radionuclide imaging agents
3 99mTc labeled folate tumor imaging agents
3.1 99mTc(CO)3+ core labeled folate imaging agents
3.2 99mTcO3+ core labeled folate imaging agents
3.3 The other 99mTc labeled folate tumor imaging agents
4 Conclusion and outlook
4.1 The design methods of radiolabeled folate-linked conjugates
4.2 The combination of the antifolate agent with the folate based imaging agents

Key words: folate receptor, folic acid, 99mTc, radiopharmaceutical, tumor imaging

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Abstract

99mTc Labeled Folate Tumor Imaging Agents