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Progress in Chemistry 2010, Vol. 22 Issue (01): 91-100 Previous Articles   Next Articles

• Invited Article •

Advances in O-Sialylation

Ye Deju1; Wang Jinfang1; Zhang Dengyou1; Feng Enguang1; Jiang Hualiang1,2; Liu Hong1**   

  1. (1. The Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;2. School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China)
  • Received: Revised: Online: Published:
  • Contact: Liu Hong E-mail:hliu@mail.shcnc.ac.cn
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Sialic acids are a family of acidic 9 carbon sugars, and are often found ?-ketosidically linked to other sugars at the termini of glycoconjugated chains in biological systems which are involved in a wide range of biological processes. Chemical synthesis of α-sialoside is one of the most difficult subjects in the field of carbohydrate chemistry. Recently, a wide spectrum of methodologies for the efficient synthesis of sialosides has been devised, which can be classified into direct O-sialylation methods and indirect O-sialylation methods based on the mode of chemical modification of sialic acid donors. This review surveys recent progress in chemical α-sialylation.

Contents
1 Introduction
2 Strategies for sialylation
2.1 Direct sialylation
2.2 Indirect sialylation
3 Conclusion

Key words: sialic acid, sialylation, N-acetylneuraminic acid

CLC Number: 

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Advances in O-Sialylation