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Progress in Chemistry 2010, Vol. 22 Issue (01): 163-172 Previous Articles   Next Articles

• Invited Article •

Current Methods and Advances in Microbial Metabolomics

Wang Zhiwen;  Ma Xianghui;  Chen Xun;  Zhao Xueming;  Chen Tao**   

  1. (Metabolic Engineering and Systems Biology Laboratory, Key Laboratory of Systems Bioengineering Ministry of Education, Edinburgh-Tianjin Joint Research Centre for Systems Biology and Synthetic Biology, Department of Biological Engineering, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China)
  • Received: Revised: Online: Published:
  • Contact: Chen Tao E-mail:chentao@tju.edu.cn
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In the post-genomic era, metabolomics(or metabonomics), genomics, transcriptomics and proteomics have become important tools in systems biology. In metabolome analysis field, microbial metabolomics has received much attention in recent years mainly because it supports and complements a wide range of microbial research areas from new drug discovery efforts to metabolic engineering. This review is mainly focused on the current methods and advances in microbial metabolomics, trying to direct the reader to the main approaches for microbial metabolome analysis, reviewing the developments of methodologies in microbial metabolomics. These developments range from microorganism cultivation, sample preparation, analytical platform and data analysis to biological interpretation. Apart from the description of the developments, we will try to discuss the potential of microbial metabolomics in metabolic engineering field, research prospect and challenge of microbial metabolomics in the future.

Contents
1 Introduction
2 Research methods of microbial metabolomics
2.1 Cell cultivation
2.2 Sample treatment
2.3 Analytical platform of microbial metabolomics
2.4 Data mining
3 Microbial metabolomics and metabolic engineering
4 Prospects

Key words: microbial metabolomics, systems biology, data mining, metabolite, metabolic engineering

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