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Progress in Chemistry 2010, Vol. 22 Issue (01): 148-152 Previous Articles   Next Articles

• Invited Article •

Application of Frontal Affinity Chromatography to Studies on Interactions of Molecules

Lu Shiyong1,2;  Wu Zhanggui2; Ye Weidong2;  Wu Guofeng2;  Pan Yibin2;  Qian Junqing3*   

  1. (1. College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China; 2. Zhejiang Medicine Co., Ltd., Shaoxing 310025,China; 3. College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China )
  • Received: Revised: Online: Published:
  • Contact: Qian Junqing E-mail:qjq@zjut.edu.cn
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Molecule interaction is important to the biological process and chemical reaction. Frontal affinity chromatography is a universal tool enabling to study the direct molecule interaction, to rank ligands and determine Kd. The review summarizeS the frontal affinity chromatography theory, the applications and the difference with other technologies that can study the direct molecule interaction.

Contents
1 Introduction
2 Theory and components of FAC
2.1 Theory of FAC
2.2 Measurement of Kd
2.3 Components of FAC
2.4 Modes of FAC
3 Applications of FAC
3.1 Analyzing protein purity
3.2 Characterizing molecular interactions
3.3 Differentiating between multiple binding sites of target molecules
3.4 Screening drugs
4 Comparison of techniques based on direct binding
5 Outlook

Key words: frontal affinity chromatography (FAC), intermolecular interaction, drug screening

CLC Number: 

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