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Progress in Chemistry 2010, Vol. 22 Issue (01): 140-147 Previous Articles   Next Articles

• Invited Article •

Methods for Detection of Volatile Organic Compounds in Human Exhaled Breath

Zhang Chen;Zhao Meiping**   

  1. (College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China)
  • Received: Revised: Online: Published:
  • Contact: Zhao Meiping E-mail:mpzhao@pku.edu.cn
  • Supported by:

    NSFC

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Over hundreds of volatile organic compounds (VOCs) have been detected in human exhaled breath. Some of the organic constituents in exhaled breath can indicate a disease state of the individual or a recent exposure to an environmental pollutant. Determination of VOCs in human breath samples shows great potential in clinical diagnosis as a noninvasive method to replace or complement measurements from blood samples. This review focuses on the recent development of various methods for detection of VOCs in human exhaled breath. The advantages and limitations of different methods are highlighted. The analytical methods and concentration data of several important disease biomarkers such as isoprene and acetone are summarized. The future development trends in this field are also briefly discussed.

Contents
1 Introduction
2 Indirect analytical methods by gas chromatography
2.1 Sampling and storage
2.2 Preconcentration
2.3 Separation and detection by gas chromatography
3 Direct analytical methods by mass spectrometry
3.1 Selected ion flow tube mass spectrometry (SIFT-MS)
3.2 Proton transfer reaction mass spectrometry (PTR-MS)
3.3 Ion-molecule reaction mass spectrometry (IMR-MS)
4 Techniques based on spectroscopy, sensors and chemiluminescence
4.1 Spectroscopy
4.2 Electronic noses
4.3 Chemiluminescence
5 Conclusion

Key words: human exhaled breath, volatile organic compounds ( VOCs ), detection methods, biomarker

CLC Number: 

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