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Progress in Chemistry 2010, Vol. 22 Issue (01): 133-139 Previous Articles   Next Articles

• Invited Article •

Application of Magnetic Control Technique in Microfluidic Chips

Shen Yuqin; Yao Bo**; Fang Qun**   

  1. （Institute of Microanalytical Systems, Department of Chemistry，Zhejiang University, Hangzhou 310058, China）
  • Received: Revised: Online: Published:
  • Contact: Yao Bo;Fang Qun E-mail:yaobo08@zju.edu.cn;fangqun@zju.edu.cn
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Magnetic force has become a promising tool for microfluid manipulation besides electrodynamic and hydrodynamic forces in microfluidic devices, because it can work under a non-contact mode without the limitations of the surface property of microchannels and the composition of working solutions, especially for capturing, sorting and manipulation of cells, virus and even single molecules. In this review, the recent developments within the field of magnetic microfluidics are presented including theory, fabrication of microcoils, design of magnetic pumps and valves, manipulation and separation based on magnetic control. The great potential of magnetic microfluidic systems in high throughput clinical diagnosis and point-of-care testing (POCT) is demonstrated and the difficulties for further application are also discussed.

Contents
1 Introduction
2 Fabrication of microcoils
3 Fluid control
3.1 Pump and valve
3.2 Mixing
4 Manipulation
4.1 Magnetic beads/cell manipulation
4.2 Micro droplets manipulation
5 Separation
5.1 Beads and cells sorting
5.2 Nucleic acids isolation
6 Bio assay
6.1 Immunoassay
6.2 Virus detection
6.3 Proteomics
6.4 NMR
7 Conclusion and prospects

Key words: microfluidic chip, magnetism control, bio-analysis

CLC Number: 

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