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Progress in Chemistry 2010, Vol. 22 Issue (01): 101-106 Previous Articles   Next Articles

• Invited Article •

Small Molecule Mimetics of α-Helix

Huang Qiang1,2; Tan Chunyan1; Jiang Yuyang1*   

  1. (1.The Key Laboratory of Chemical Biology, Guangdong Province, The Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China; 2. Henan University of Technology, Zhengzhou 450052, China)
  • Received: Revised: Online: Published:
  • Contact: Jiang Yuyang E-mail:jiangyy@sz.tsinghua.edu.cn
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This paper reviewes the progress of small molecule mimics of α-helix in recent years. It introduces the importance of α-helix for protein interaction and the application of α-helix mimics in medicinal chemistry. This review also summarizes the new progress of small molecule mimics of α-helix based on different skeleton structures, such as phenyl, amide, pyridazine and other heterocyclic compounds. The application of α-helix mimics in the field of protein interaction inhibitors is discussed. At last, we summarize some disadvantages of the small molecule mimics of α-helix which have been reported in recent years and describe the future trend in this field.

Contents
1 Introduction
2 Small molecules of α-helix mimics
2.1 Phenyl compounds and their analogues
2.2 Amides
2.3 Heterocyclic compounds
3 Conclusion

Key words: small molecules, α-helix mimics, protein interaction, inhibitors

CLC Number: 

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Abstract

Small Molecule Mimetics of α-Helix