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Progress in Chemistry 2009, Vol. 21 Issue (12): 2689-2695 Previous Articles   Next Articles

• Review •

Polymer-Silica Hybrid Materials and Their Applications for Controlled Drug Release

Liu Qiong;  Yang Tingting;  Gao Qing;  Yuan Jianjun;  Cheng Shiyuan**   

  1. (School of Materials Science and Engineering, Hubei University, Wuhan 430062, China)
  • Received: Revised: Online: Published:
  • Contact: Cheng Shiyuan E-mail:sycheng@hubu.edu.cn
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Polymer carriers for drug release have the advantages such as controlled concentration of the released drug, high drug utilization in organism and targeting therapy. However, some polymers have disadvantages such as low mechanical strength, poor chemical stability and undesirable biocompatibility.Silica is porous and non-toxic and possesses advantages such as good biocompatibility, high chemical and mechanical stabilities and easy surface functionalization. But for some silica carriers, it is difficult to load large drug molecules, to have high drug loading or to achieve targeting therapy. Polymer-silica hybrid materials may combine the advantages of polymer and silica carriers in drug delivery and eliminate their disadvantages. Based on the properties of the polymers and the functions of the polymer/silica hybrid materials, controlled drug release systems, including temperature-sensitive polymer/silica, polyelectrolyte/silica, biopolymer/silica, and other polymer/silica hybrid materials are reviewed in this article. The research trends of this field are also briefly discussed.

Contents
1 Introduction
2 Temperature-sensitive polymer/silica hybrid materials
3 Polyelectrolyte/silica hybrid materials
4 Biopolymer/silica hybrid materials
5 Other polymer/silica hybrid materials
6 Prospects

Key words: controlled drug release, polymer/silica hybrid materials, biocompatibility

CLC Number: 

[ 1 ] 　梁旭东(Liang X D) , 李雪光(Li X G) , 付瑶(Fu Y) 等. 过程工程学报(The Chinese Journal of Process Engineering) , 2008 , 8 (3) : 595 —598
[ 2 ] 　陈建海(Chen J H) . 药用高分子材料与现代药剂(Medical Polymer Materials and Modern Pharmacy) . 北京: 科学出版社(Beijing : Science Press) , 2003
[ 3 ] 　陈莉(Chen L) . 智能高分子材料( Intelligent Polymers) . 北京: 化学工业出版社(Beijing : Chemical Industry Press) , 2005. 69
[ 4 ] 　何京涛(He J T) . 北京化工大学博士论文(Doctoral Dissertation of Beijing University of Chemical Technology) , 2005
[ 5 ] 　田威(Tian W) , 范晓东(Fan X D) , 陈卫星(Chen W X) 等. 高分子材料科学与工程( Polymer Materials Science and Engineering) , 2006 , 22 (4) : 19 —23
[ 6 ] 　Yagüe C , Moros M, GrazúV , et al . Chemical Engineering Journal , 2008 , 137 : 45 —53
[ 7 ] 　贾伟(Jia W) , 高文远( Gao W Y) . 药物控释新剂型(New Formulation of Drug Controlled Release) . 北京: 化学工业出版社现代生物技术与医药科技出版中心(Beijing : Chemical Industry
Press) , 2005. 373
[ 8 ] 　Dinarvand R D , Emanuele A D. J . Control . Rel . , 1995 , 36 (3) : 221 —227
[ 9 ] 　Bae Y H , Okano T, Hsu R , et al . Macromol . Chem. Rapid. Commun. , 1987 , 8 (10) : 481
[10 ] 　黄月文(Huang YW) , 罗宣干(Luo X G) , 卓仁禧(Zhuo R X) . 高分子材料科学与工程( Polymer Materials Science and Engineering) , 1998 , 14 (6) : 141 —147
[11 ] 　Chang J H , Kim KJ , Shin Y K. Bull . Korean Chem. Soc. , 2004 , 25 (8) : 1257 —1260
[12 ] 　Chang J H , Shim C H , Kim B J , et al . Adv. Mater. , 2005 , 17 (5) : 634 —637
[13 ] 　Chang J H , Shim C H , Kim KJ . Key Engineering Materials , 2005 , 287 : 39 —43
[14 ] 　邓勇辉(Deng Y H) . 复旦大学博士论文(Doctoral Dissertation of Fudan University) , 2005
[15 ] 　Guo J , Yang W L , Wang C C , et al . Chem. Mater. , 2006 , 18 : 5554 —5562
[16 ] 　Bikram M, Gobin A M, Whitmire R E , et al . Journal of Controlled Release , 2007 , 123 : 219 —227
[17 ] 　Zhu S M, Zhou Z Y, Zhang D , et al . Microporous and Mesoporous Materials , 2007 , 106 : 56 —61
[18 ] 　Zhou Z Y, Zhu S M, Zhang D. J . Mater. Chem. , 2007 , 17 : 2428 —2433
[19 ] 　Wei H , Cheng C , Chang C , et al . Langmuir , 2008 , 24 : 4564 —4570
[20 ] 　Kosmilski M. J . Colloid Interface Sci . , 2004 , 275 : 214 —224
[21 ] 　Zhu Y F , Shi J L , Shen W H , et al . Angew. Chem. Int . Ed. , 2005 , 44 : 5083 —5087
[22 ] 　Zhu Y F , Shi J L. Microporous and Mesoporous Materials , 2007 , 103 : 243 —249
[23 ] 　Yang Q , Wang S C , Fan P W, et al . Chem. Mater. , 2005 , 17 : 5999 —6003
[24 ] 　Fuller J E , Zugates G T, Ferreira L S , et al . Biomaterials , 2008 , 29 : 1526 —1532
[25 ] 　Einerson N J , Stevens K R , Kao W J . Biomaterials , 2002 , 24 : 509 —523
[26 ] 　Olsen D , Yang C , Bodo M, et al . Drug Delivery Rev. , 2003 , 55 : 1547 —1567
[27 ] 　Saravanan M, Bhaskar K, Maharajan G, et al . Int . J . Pharm. , 2004 , 283 : 71 —82
[28 ] 　Young S , Wong M, Tabata Y, et al . J . Controlled Release , 2005 , 109 : 256 —274
[29 ] 　Coradin T, Mercey E , Lisnard L , et al . Chem. Commun. , 2001 , 2496 —2497
[30 ] 　Boissière M, Meadows P J , Brayner R , et al . J . Mater. Chem. , 2006 , 16 : 1178 —1182
[31 ] 　Boissière M, Allouche J , Chanéac C , et al . International Journal of Pharmaceutics , 2007 , 344 : 128 —134
[32 ] 　Allouche J , Boissière M, Hélary C , et al . J . Mater. Chem. , 2006 , 16 : 3120 —3125
[33 ] 　Ohta KM, Fuji M, Takei T, et al . European Journal of Pharmaceutical Sciences , 2005 , 26 : 87 —96
[34 ] 　Huo Q , Liu J , Wang L Q , et al . J . Am. Chem. Soc. , 2006 , 128 : 6447 —6453
[35 ] 　Li Z Z, Wen L X, Shao L , et al . J . Controlled Release , 2004 , 98 : 245 —254
[36 ] 　Arruebo M, Fernandez2Pacheco R , Irusta S , et al . Nanotechnology , 2006 , 17 : 4057 —4064
[37 ] 　Yang J , Lee J , Kang J , et al . Langmuir , 2008 , 24 : 3417 —3421
[38 ] 　Yagüe C , Moros M, GrazúV , at al . Chemical Engineering Journal , 2008 , 137 : 45 —53
[39 ] 　Son Y H , Park M, Choy Y B , et al . Chem. Commun. , 2007 , 2799 —2801
[40 ] 　Zhou Z Y, Zhu S M, Zhang D , et al . Chemistry Letters , 2006 , 35 (12) : 1426 —1427
[41 ] 　Zhu S M, Zhang D , Yang N. J . Nanopart . Res. , 2009 , 11 : 561 —568
[42 ] 　李长军(Li C J ) , 朱家壁(Zhu J B) , 郑春丽(Zheng C L) . 中国新药杂志( Chinese Journal of New Drug) , 2008 , 17 ( 2) : 100 —118
[43 ] 　Grayson A C R , Choi I S , Tyler B M, et al . Nat . Mater. , 2003 , 2 : 767 —772
[44 ] 　Kim HJ , Matsuda H , Zhou H S , et al . Adv. Mater. , 2006 , 18 : 3083 —3088
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