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Progress in Chemistry 2009, Vol. 21 Issue (12): 2682-2688 Previous Articles   Next Articles

• Review •

Layer-by-Layer Assembly: the New Approach for Advanced Drug Release System

Sun Jiekan;  Wang Xuefei;  Ji Jian**   

  1. (Key Laboratory of Macromolecule Synthesis and Functionalization of Minister of Education, Department of Polymer Science and Engineering,  Zhejiang University, Hangzhou 310027, China)
  • Received: Revised: Online: Published:
  • Contact: Ji Jian E-mail:jijian@zju.edu.cn
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The comprising drug releasing components together with functional prosthetic implant provide the new possibility to improve the functionality in prosthetic implant. The layer-by-layer assembly (LBL) method has been regarded as the most attractive method for advanced drug release coating because it possesses extraordinary advantages such as easy operation, fine control over coating’s composition and outstanding capability of constructing wide ranges of biomolecules onto different substrates and so on. This review gives a brief instruction of current research on LBL as a new approach for advanced drug release coatings for biomedical implant. The advantages as well as the challenges of LBL technique for local drug release films are summarized. Future developments in the field are also discussed.

Contents
1 Constructing drug controlled release systems via LBL
1.1 Drugs as a building block in LBL
1.2 Post diffusion
1.3 Pro-drug
1.4 Precursor assembly
2 Release behavior of multilayers
2.1 The effect of multilayer structure
2.2 Stimulus-response release
3 Research of factional multilayers
3.1 Antibacterial multilayers
3.2 Multilayers for revascularization
3.3 Multilayers for gene delivery
4 Prospects

Key words: layer-by-layer assembly, multilayer films, drug controlled release

CLC Number: 

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