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Progress in Chemistry 2009, Vol. 21 Issue (11): 2397-2410 Previous Articles   Next Articles

• Special issues •

Biochip Development

Xiao Shoujun**; Chen Ling; Xu Ning   

  1. (School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, China)
  • Received: Online: Published:
  • Contact: Xiao Shoujun E-mail:sjxiao@nju.edu.cn
  • Supported by:

    NSFC

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Biochip is one of the most breakthrough technologies developed in the recent twenty years. In this review we first introduce the planar DNA and protein microarrays, then focus on the newly developed high technologies of SELDI (surface enhanced laser desorption/ionization) biochip, high throughput DNA sequencing, high throughput photonic crystal micro-bead bio-coding, three dimensional gel-pad biochip, and microfluidic biochip. We describe the advantages of each type of biochips, limits of its applications, and challenges to be solved. The future of biochip technologies will be prosperous.

Contents
1 Introduction
2 DNA microarray
2.1 Introduction of DNA miroarray
2.2 Preparation of DNA Microarray
3 Protein microarray
3.1 Introduction of protein microarray
3.2 Preparation of protein microarray
4 Biochip read-out mechanism
4.1 Fluorescence
4.2 Mass spectroscopy
4.3 Electrical read-out mechanism
5 SELDI mass protein biochip
6 High throughput DNA sequencing
7 High throughput photonic crystal micro-bead bio-coding
8 Three dimensional biochip
8.1 3-D gel-pad microarray
8.2 3-D porous silicon biochip
9 Microfluidic biochip
10 Outlook

Key words: biochip, read-out mechanism, protein microarray, three dimensional biochip, high throughput micro-bead bio-coding, high throughput DNA sequencing, microfluidic biochip

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Abstract

Biochip Development