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Progress in Chemistry 2009, Vol. 21 Issue (11): 2388-2396 Previous Articles   Next Articles

• Special issues •

Separation Science in the Context of Metabonomics: Current Platforms and Future Trends

Wang Jiangshan;   Kong Hongwei;   Lu Xin;   Zhao Xinjie;  Xu Guowang**   

  1. (CAS Key laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China)
  • Received: Online: Published:
  • Contact: Xu Guowang E-mail:xugw@dicp.ac.cn
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As an indispensable technique in the context of systems biology, metabonomics/metabolomics has been proposed for over ten years and has become the focus of life sciences in the fields of drug development, healthy and plant research. Metabonomics/metabolomics aims at the downstream molecules (metabolites) of metabolism to reveal the phenomenon and mechanisms of lives by means of combination of analytical chemistry and bioinformatics. This review focuses on the currently new advances of separation sciences including gas chromatography, liquid chromatography and capillary electrophoresis in metabonomics/metabolomics as well as its applications in medicine, drug discovery and development, plant and microbe related fields, especially in the authors’ laboratory.

Contents
1 Introduction
2 Separation sciences in metabonomics
2.1 Gas chromatography
2.2 Liquid chromatography
2.3 Capillary electrophoresis
3 Perspectives

Key words: metabonomics, metabolomics, systems biology, separation science

CLC Number: 

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