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Progress in Chemistry 2009, Vol. 21 Issue (11): 2379-2387 Previous Articles   Next Articles

• Special issues •

Electrochemical Detection for Arrayed Electrode Chips

Xu Danke; Chen Hongyuan*   

  1. (Key Lab of Analytical Chemistry for Life Science, Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China)
  • Received: Online: Published:
  • Contact: Chen Hongyuan E-mail:hychen@nju.edu.cn
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Ananlytical chemistry for life science is an interdisciplinary scientific field to develop novel analytical principles, methods and techniques for detecting chemical molecules and providing scientific data and information for life science. Combining electrochemical methods with microarray technology, electrochemical biochips are being accelerated towards integration, throughput, miniaturization, automation. Recent progresses in the development of electrochemical detection methods for DNA arrays and protein arrays as well as aptamer arrays are summarized in this review. In the case of electrochemical DNA arrays, numerous fabrication methods of DNA capture probes for high throughput and focused DNA arrays are presented. Electrochemical detection is focused on voltammetry by using various electrochemical probes or label-free approach. The development of arrayed electrodes immobilized with antibodies and aptamers is also discussed, in which voltammetry and electrochemical impedance measurements have been used to assay multiplexed protein targets.

Contents
1 Electrochemical detection for DNA chips
1.1 Focused DNA chips
1.2 High throughput DNA chips
2 Electrochemical detection for protein array chips
2.1 Enzyme arrayed electrodes
2.2 Electrochemical multiplex measurement for proteins
3 Aptamer arrays

CLC Number: 

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