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Progress in Chemistry 2009, Vol. 21 Issue (10): 2093-2099 Previous Articles   Next Articles

• Review •

Chromium Complexes with Cleaving DNA Activity

Yue Lei;  Zhou Yinzhuang **   

  1. (Department of Chemistry, Capital Normal University, Beijing 100048, China)
  • Received: Revised: Online: Published:
  • Contact: Zhou Yinzhuang E-mail:zhouyz7813@x263.net
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Study on cleavage DNA activity of chromium complexes attracts aboard attention owing to theirs important application prospects in medical, pharmaceutical and biology fields. In this paper, the research progress of chromium complexes with cleaving DNA activity is reviewed. The studies of the chromium complexes of various coordination mode and structure-activity relationship in this field are introduced The action mechanism of the chromium complexes are summarized. Finally, the research and development trends of chromium complexes with different valences are put forward.

Contents
1 Introduction
2 Study on cleavage DNA activity of chromium complexes
2.1 Metal Cr(Ⅲ) complexes
2.2 Metal Cr(Ⅴ)O complexes
2.3 Metal Cr(Ⅵ) complexes
3 The action mechanism of the metal chromium complexes with DNA
4 Conclusion and prospective

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