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Progress in Chemistry 2009, Vol. 21 Issue (09): 1905-1921 Previous Articles   Next Articles

• Review •

Applications of Nanotechnology in Capillary Electrophoresis and Microfluidic Chip Electrophoresis Biomolecular Separations

Geng Lina1 ; |Jiang Ping1 ; |Xu Jiandong1 ; |Che Baoquan2 ; |Qu Feng1 ; |Deng Yulin1**   

  1. (1.School of Life Science and Technology| Beijing Institute of Technology| Beijing 100081, China|2. Beijing Institute for Drug Control| Beijing 100035| China)
  • Received: Revised: Online: Published:
  • Contact: Deng Yulin E-mail:deng@bit.edu.cn
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In this paper, the applications of nanotechnology in capillary electrophoresis and microfuidic chip biomolecular are reviewed. The nanotechnology is used to improve seperation effect by the nanomaterials of gold, silica, polymer, metal oxide and carbon nanotube, and the nanostructures including nanopillars and nanochannels, prepared by microelectromechanical(MEMS) technologies, chemical synthesis or self-assembly. The development of this field is also proposed.

Contents
1 Introduction
2 The applications of nanomaterials in capillary electrophoresis and chip electrophoresis
2.1 The application methods of nanomaterials in capillary electrophoresis
2.2 Applications of different kinds of nanomaterials in capillary electrophoresis
2.3 The applications of nanomaterials in chip bioelectrophoresis separation
3 The microfluidic chip electrophoresis seperation based on the construction of 3D-nanostructure
3.1 The sieving separations based on size differences
3.2 Separations based on entropic difference
3.3 Anisotropic separation
3.4 Brownian diffusion separation
3.5 Application of nanotechnologies in chip chromatography and chip electrochromatography
3.6 Techniques of nanochannels and nanofluidics
4 Conclusion and perspectives

CLC Number: 

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