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Progress in Chemistry 2009, Vol. 21 Issue (04): 739-746 Previous Articles   Next Articles

• Review •

Application of Fluorescent Conjugated Polymers in Detecting Biomacromolecules

Zhi Junge1**, Xu Xiuling1, Shen Jinbo2, Zhao Wei2, Tong Bin2, Dong Yuping2**   

  1. (1. Department of Chemistry, Beijing Institute of Technology, Beijing 100081, China; 2. Department of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China)
  • Received: Revised: Online: Published:
  • Contact: Zhi Junge;Dong Yuping E-mail:zhijunge@bit.edu.cn; chdongyp@bit.edu.cn
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 Conjugated polymers exhibit excellent electronic and luminescent properties due to their special π-electronic system and conjugated delocalized structure. The fluorescence intensity and emission wavelength of them vary obviously and selectively with different interaction between conjugated polymer and different detected compounds. The fluorescence signals deriving from the interaction between conjugated polymer and detected compounds are often amplified because the effective electrons and energy transfer along the main-chain of conjugated polymers, which can respond high-sensibly to analytes and exceed to that of small model compound of conjugated polymer. The novel chemical and biological sensors based on conjugated polymers are developed. Many conjugated polymers, including poly(thiophene)s, Poly(fluorene-co-phenylene)s, poly(phenyleneethynylene)s and poly(phenylene vinylene)s are used to detect biomacromolecules. In the present paper, the recent progress of conjugated polymers as biosensors is summarized, and the assay of protein, DNA and toxin using fluorescence conjugated polymers is discussed.

Contents
1 Introduction
2 Application of conjugated polymers in detecting biomacromolecules
2.1 Detecting of protein
2.2 Detecting of DNA
2.3 Detecting of toxin
3 Conclusion

Key words: fluorescence conjugated polymers, biosensors, fluorescence quenching

CLC Number: 

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