中文
Earlier issues
Announcement
More
Progress in Chemistry 2009, Vol. 21 Issue (04): 732-738 Previous Articles   Next Articles

• Review •

Aptamer-Based Biosensor

Zheng Jing1,2** ;  He Pingang1** ; Fang Yuzhi1   

  1. (1. Department of Chemistry, East China Normal University, Shanghai 200062, China;
     2. Department of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China )
  • Received: Revised: Online: Published:
  • Contact: Zheng Jing; He Pingang E-mail:kkzhengjing707@163.com; pghe@chem.ecnu.edu.cn
PDF ( 3026 ) Cited
Export

EndNote

Ris

BibTeX

Protein detection has been a topic of significant interest for proteomics. Intense research activities are carried out worldwide to develop rapid, specific and sensitive detection devices for protein, while the detection methodologies for protein based on antibodies cannot meet the demand of the human proteome. Now aptamers have been emerging as a new protein recognition element in wide range of bioassays and have attracted a considerable attention due to their ability to bind target protein with high affinity and specificity and have many advantages over antibodies, including simpler synthesis, easier storage, reproducibility, and wider applicability. These properties make aptamers ideal candidates as protein recognition elements. This review highlights the origin(including the basic principle of SELEX), characteristics of the aptamer. The basic principle, classification and application of the aptamer based biosensor are reviewed and discussed. Finally the prospect of the aptamer based biosenor is proposed.

Contents
1 Introduction
2 Aptamer
2.1 SELEX technology
2.2 Characteristics of aptamer
3 Principle of the aptamer based biosensor
4 Classification of the aptamer based biosensor
4.1 Optical aptamer based biosensor
4.2 Piezoelectric aptamer based biosensor
4.3 Electrochemical aptamer based biosensor
5 Application of nanoparticles in aptamer based biosensor
6 Application of the aptamer based biosensor
7 Prospoects of the aptamer based biosensor

Key words: aptamers, biosensors, proteins

CLC Number: 

[ 1 ] 　Tuerk C , Goldberg L. Science , 1990 , 249 : 505 —510
[ 2 ] 　Ellington A D , Szostak J W. Nature , 1990 , 346 : 818 —822
[ 3 ] 　Jay H , Michael P R , Sulay J , et al . Reviews in Molecular Biotechnology , 2000 , 74 : 15 —25
[ 4 ] 　Soukup GA , Breaker R R. Nanotechnology , 1999 , 17 : 469 —476
[ 5 ] 　Shultzaberger R , Schneider T. Nucleic Acids Res. , 1999 , 27 :882 —887
[ 6 ] 　Andrei P D , Maxim B , Victor O , et al . Anal . Chem. , 2006 , 78 :3171 —3178
[ 7 ] 　Rye P D , Nustad K. Biotechniques , 2001 , 30 : 290 —294
[ 8 ] 　Hermann T, Dinshaw J P. Science , 2000 , 287 : 820 —825
[ 9 ] 　Nguyen D H , DeFina S C , Fink W H , et al . J . Am. Chem. Soc. ,2002 , 124 : 15081 —15084
[10 ] 　Clark S L , Remcho V T. Electrophoresis , 2002 , 23 : 1335 —1340
[11 ] 　Brody E N , Gold L. J . Biotechnol . , 2000 , 74 : 5 —13
[12 ] 　Jenison R D , Gill S C , Pardi A , et al . Science , 1994 , 263 :1425 —1429
[13 ] 　Lee J F , Hesselberth J R , Meyers L A , et al . Nucleic Acids Res. ,2004 , 32 : 95 —100
[14 ] 　Patel D J , Suri A K. Rev. Mol . Biotechnol . , 2000 , 74 : 39 —60
[15 ] 　Lee M, Walt D R. Analytical Biochemistry , 2000 , 282 : 142 —146
[16 ] 　McCauley T G, Hamaguchi N , Stanton M. Analytical Biochemistry ,2003 , 319 : 244 —250
[17 ] 　Davis J J , Tkac J , Laurenson S , et al . Anal . Chem. , 2007 , 79 :1089 —1096
[18 ] 　Van Ryk D I , Venkatesan S. J . Biol . Chem. , 1999 , 274 : 17452 —17463
[19 ] 　Kraus E , Janes W, Barclay A N. The Journal of Immunology , 1998 ,160 : 5209 —5212
[20 ] 　Murphy M B , Fuller S T, Richardson P M, et al . Nucleic Acids Research , 2003 , 31 : e110
[21 ] 　Li Y, Lee HJ , Corn R M. Anal . Chem. , 2007 , 79 : 1082 —1088
[22 ] 　Fang X, Li J J , Tan W. Anal . Chem. , 2000 , 72 : 3280 —3285
[23 ] 　Kirby R , Cho E J , Gehrke B , et al . Anal . Chem. , 2004 , 76 :4066 —4075
[24 ] 　Pavlov V , Xiao Y, Shlyahovsky B , et al . J . Am. Chem. Soc. ,2004 , 126 : 11768 —11769
[25 ] 　Heckel A , Mayer G. J . Am. Chem. Soc. , 2005 , 127 : 822 —823
[26 ] 　Heyduk E , Heyduk T. Anal . Chem. , 2005 , 77 : 1147 —1156
[27 ] 　Giridharan G, Jay R U , Douglas F H. Anal . Chem. , 2005 , 77 :1963 —1970
[28 ] 　徒永华(Tu Y H) , 程圭芳(Cheng G F) , 林莉(Lin L) 等. 高等学校化学学报(Chemical Journal of Chinese University) , 2006 ,27 : 2266 —2270
[29 ] 　Hianik T, OstatnáV , ZaijacováZ, et al . Bioorg. Med. Chem.Lett . , 2005 , 15 : 291 —295
[30 ] 　Bini A , Minunni M, Tombelli S , et al . Anal . Chem. , 2007 , 79 :3016 —3019
[31 ] 　Liss M, Petersen B , Wolf H , et al . Anal . Chem. , 2002 , 74 :4488 —4495
[32 ] 　Minunni M, Tombelli S , Gullotto A , et al . Biosensors and Bioelectronics , 2004 , 20 : 1149 —1156
[33 ] 　Gronewold T M A , Glass S , Quandt E , et al . Biosensors and Bioelectronics , 2005 , 20 : 2044 —2052
[34 ] 　Schlensog M D , Gronewold T M A , Tewes M, et al . Sens.Actuators , 2004 , 10 : 308 —315
[35 ] 　Xu D , Xu D , Yu X, et al . Anal . Chem. , 2005 , 77 : 5107 —5113
[36 ] 　Radi A E , Acero S J L , Baldrich E , et al . Anal . Chem. , 2005 ,77 : 6320 —6323
[37 ] 　Ikebukuro K, Kiyohara C , Sode K. Biosensors and Bioelectronics ,2005 , 20 : 2168 —2172
[38 ] 　Lai R Y, Plaxco K W, Heeger A J . Anal . Chem. , 2007 , 79 :229 —233
[39 ] 　Le Floch F , Ho H A , Leclerc M. Anal . Chem. , 2006 , 78 : 4727 —4731
[40 ] 　Hansen J A , Wang J , Kawde A N , et al . J . Am. Chem. Soc. ,2006 , 128 : 2228 —2229
[41 ] 　Zuo X, Song S , Zhang J , et al . J . Am. Chem. Soc. , 2007 , 129 :1042 —1043
[42 ] 　Min S H , Abigail K R , Byung-Keun O , et al . Angew. Chem. ,2006 , 118 : 1839 —1842
[43 ] 　Hye-Mi S , Keehoon W, Yong H K, et al . J . Am. Chem. Soc. ,2005 , 127 : 11906 —11907
[44 ] 　Valeri P , Yi X, Bella S , et al . J . Am. Chem. Soc. , 2004 , 126 :11768 —11769
[45 ] 　Wang J , Liu GD , Mark H. Anal . Chem. , 2006 , 78 : 6974 —6979
[46 ] 　Wang L H , Zhang J , Wang X. Gold Bulletin , 2008 , 41 : 37 —41
[47 ] 　Levy M, Cater S F , Ellington A D. ChemBioChem. , 2005 , 6 :2163 —2166
[48 ] 　Joshua K H , Joshua E S , Colin D M, et al . Anal . Chem. , 2006 ,78 : 2918 —2924
[49 ] 　Wang J , Wang L H , Liu X F , et al . Advanced Materials , 2007 ,19 : 3943 —3946
[50 ] 　Wang L H , Liu X F , Fan C H , et al . Chem. Commun. , 2006 , 36 :3780 —3782
[51 ] 　Zheng J , Lin L , Cheng G F , et al . Science in China Series B-Chemistry , 2007 , 50 : 351 —357
[52 ] 　Zheng J , Feng W J , Lin L , et al . Biosensors and Bioelectronics ,2007 , 23 : 341 —347
[53 ] 　Jiang Y X, Zhu C F , Ling L S , et al . Anal . Chem. , 2003 , 75 :2112 —2116
[54 ] 　Lai R Y, Plaxco KW, Heeger AJ , et al . Anal . Chem. , 2007 , 79 :229 —233
[55 ] 　Javeri S D , Kirby R , Conrad R , et al . J . Am. Chem. Soc. , 2000 ,122 : 2469 —2473
[56 ] 　Fang X H , Cao Z H , Beck T, et al . Anal . Chem. , 2001 , 73 :5752 —5757
[57 ] 　Nutiu R , Li Y F. J . Am. Chem. Soc. , 2003 , 125 : 4771 —4778
[58 ] 　Rupcich N , Nutiu R , Li Y F. Angew Chem. , 2006 , 118 : 3373 —3377
[59 ] 　Yamamoto R , Baba T, Kumar P K. Genes to Cells , 2000 , 5 : 389 —396
[60 ] 　Su S , Nutiu R , Filipe C D M, et al . Langmuir , 2007 , 23 : 1300 —1302
[61 ] 　周翠松(Zhou C S) , 江雅新(Jiang Y X) , 汪俊(Wang J ) 等. 高等学校化学学报(Chemical Journal of Chinese University) , 2006 ,27 : 826 —829
[62 ] 　Stojanovic M N , Landry D W. J . Am. Chem. Soc. , 2002 , 124 :9678 —9679
[63 ] 　Baker B R , Lai R Y, Wood M S , et al . J . Am. Chem. Soc. ,2006 , 128 : 3138 —3139
[64 ] 　Jiang Y X, Fang X H , Bai C L. Anal . Chem. , 2004 , 76 : 5230 —5235
[65 ] 　Wang J , Jiang Y X, Fang X H , et al . Anal . Chem. , 2005 , 77 :3542 —3546
[66 ] 　Ho H A , Leclerc M. J . Am. Chem. Soc. , 2004 , 126 : 1384 —1387
[67 ] 　Kirham P M, Neri D , Winter G, et al . J . Mol . Biol . , 1997 , 285 :909 —915
[68 ] 　Rhodes A , Deakin A , Spaull J , et al . J . Bio. Chem. , 2000 , 275 :28555 —28561
[69 ] 　White R R , Sullenger B A , Rusconi C P. J . Clin. Invest . , 2000 ,106 : 929 —934
[70 ] 　Brody E N , Gold L. Rev. Mol . Biotechnol . , 2000 , 74 : 5 —13
[1] Yiming Chen, Huiying Li, Peng Ni, Yan Fang, Haiqing Liu, Yunxiang Weng. Catechol Hydrogel as Wet Tissue Adhesive [J]. Progress in Chemistry, 2023, 35(4): 560-576.
[2] Yanyan Wang, Limin Chen, Siyang Li, Luhua Lai. How Intrinsically Disordered Proteins Modulate Biomolecular Condensates [J]. Progress in Chemistry, 2022, 34(7): 1610-1618.
[3] Huayue Sun, Xianxin Xiang, Tingyi Yan, Lijun Qu, Guangyao Zhang, Xueji Zhang. Wearable Biosensors Based on Smart Fibers and Textiles [J]. Progress in Chemistry, 2022, 34(12): 2604-2618.
[4] Weijia Zhang, Xueguang Shao, Wensheng Cai. Molecular Simulation of the Antifreeze Mechanism of Antifreeze Proteins [J]. Progress in Chemistry, 2021, 33(10): 1797-1811.
[5] Jiaen Xie, Yuheng Luo, Qianling Zhang, Pingyu Zhang. Metal Complexes in Application of Two-Photon Luminescence Probes [J]. Progress in Chemistry, 2021, 33(1): 111-123.
[6] Bin Qiao, Hongfei Chen, Hui Zhang, Chenxin Cai. Analysis and Detection of Tumor Exosomes [J]. Progress in Chemistry, 2019, 31(6): 847-857.
[7] Yangyang Zhou, Jian Zhong, Xiaojun Bian, Gang Liu, Liang Li, Juan Yan. Application of Signal Amplification Technology in the Area of Food Safety Detection [J]. Progress in Chemistry, 2018, 30(2/3): 206-224.
[8] Deng Wangping, Wang Lihua, Song Shiping, Zuo Xiaolei. Biosensors in POCT Application [J]. Progress in Chemistry, 2016, 28(9): 1341-1350.
[9] Ding Peng, Chen Xian, Li Xiuling, Qing Guangyan, Sun Taolei, Liang Xinmiao. The Separation and Enrichment of Glycoproteins or Glycopeptides Based on Nanoparticles [J]. Progress in Chemistry, 2015, 27(11): 1628-1639.
[10] Cao Ya, Zhu Xiaoli, Zhao Jing, Li Hao, Li Genxi. Electrochemical Analysis of Tumor Marker Proteins [J]. Progress in Chemistry, 2015, 27(1): 1-10.
[11] Lin Yingwu. Dimerization, Oligomerization and Polymerization of Heme Proteins [J]. Progress in Chemistry, 2014, 26(06): 987-995.
[12] Zhong Dagen, Liu Zonghua, Zuo Qinhua, Xue Wei. Interaction of Polymeric Nanomaterials with Plasma Proteins [J]. Progress in Chemistry, 2014, 26(04): 638-646.
[13] Chen Xuwei, Mao Quanxing, Wang Jianhua*. Ionic Liquids in Extraction/Separation of Proteins [J]. Progress in Chemistry, 2013, 25(05): 661-668.
[14] Song Yingpan, Feng Miao, Zhan Hongbing*. Application of Graphene Edge Effect in Electrochemical Biosensors [J]. Progress in Chemistry, 2013, 25(05): 698-706.
[15] Xu Caihong, Zhao Yaqin, Yang Binsheng*. Mediating Roles of Metal Ions in the Structures and Functions of Metalloproteins [J]. Progress in Chemistry, 2013, 25(04): 520-529.
Viewed
Full text


Abstract

Aptamer-Based Biosensor