中文
Announcement
More
Progress in Chemistry 2009, Vol. 21 Issue (04): 724-731 Previous Articles   Next Articles

• Review •

Aptamer-Based Electrochemical Biosensors

Lei Lihong1,2; Fu Yingchun1; Xu Xiahong1;   Xie Qingji1**; Yao Shouzhuo1   

  1. (1. Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China; 2. The Medical College of Hunan Normal University, Changsha 410081, China)
  • Received: Revised: Online: Published:
  • Contact: Xie Qingji E-mail:xieqj@hunnu.edu.cn
PDF ( 3738 ) Cited
Export

EndNote

Ris

BibTeX

The aptamers are DNA or RNA oligonucleotides selected in vitro that can bind their targets with high affinity and high specificity. As a kind of new and special recognition molecules, the aptamers present notable advantages over conventional recognition molecules, such as antibody, thus they have received great attention and been widely utilized in various fields involving molecular recognition and relevant applications, especially in biosensing. In this review, we briefly summarize the recent progress of aptamer-based electrochemical biosensors, involving introduction of aptamer and “signal-on”-type, “signal-off”-type, enzyme-labeled, nanoparticle-labeled and nonlabeled aptamer-based electrochemical biosensors.

Contents
1 Brief introduction of aptamer
2 Aptamer-based electrochemical biosensor
2.1 Labeled aptamer-based electrochemical biosensor
2.2 Non-labeled aptamer-based electrochemical biosensor
3 Conclusions and perspectives

CLC Number: 

[ 1 ]  Ellington A D , Szostak J W. Nature , 1990 , 346 : 818 —822
[ 2 ]  Tuerk C , Gold L. Science , 1990 , 249 : 505 —510
[ 3 ]  Jayasena S D. Clin. Chem. , 1999 , 45 : 1628 —1631
[ 4 ]  Ellington A D , Szostak J W. Nature (London) , 1992 , 355 : 850 —851
[ 5 ]  刘晓静(Liu XJ ) , 刘韧人(Liu R R) , 顾长国(Gu C G) . 生理科学进展(Prog. Physiol . Sci . ) , 2004 , 35 : 374 —378
[ 6 ]  王成刚(Wang C G) , 莫志宏(Mo Z H) . 生物医学工程学杂志(J . Biomed. Eng. ) , 2006 , 23 : 463 —466
[ 7 ]  Mairal T, ; zalp V C , Sánchez P L , et al . Anal . Bioanal . Chem. ,2008 , 390 : 989 —1007
[ 8 ]  Proske D , Blank M, Buhmann R , et al . Appl . Microbiol .Biotechnol . , 2005 , 69 : 367 —374
[ 9 ]  Tombelli S , Minunni M, Mascini M. Biosens. Bioelectron. , 2005 ,20 : 2424 —2434
[10 ]  谢海燕(Xie H Y) , 陈薛钗(Chen X C) , 邓玉林(Deng YL) .化学进展(Prog. Chem. ) , 2007 , 19 : 1026 —1033
[11 ]  漆红兰(Qi HL) , 李延(Li Y) , 李晓霞(Li X X) . 化学传感器(Chemical Sensors) , 2007 , 27 : 1 —8
[12 ]  Song S P , Wang L H , Li J , et al . Trends Anal . Chem. , 2008 , 27(2) : 108 —117
[13 ]  Willner I , Zayats M. Angew. Chem. Int . Ed. , 2007 , 46 : 6408 —6418
[14 ]  Tang J , Xie J , Shao N S , et al . Electrophoresis , 2006 , 27 : 1303 —1311
[15 ]  Zhang H Q , Li X F , Le X C. J . Am. Chem. Soc. , 2008 , 130 :34 —35
[16 ]  Berezovski M, Drabovich A , Krylova S M, et al . J . Am. Chem.Soc. , 2005 , 127 : 3165 —3171
[17 ]  Cole J R , Dick L W, McGown L B. et al . Anal . Chem. , 2007 ,79 : 273 —279
[18 ]  Huang Y F , Chang H T. Anal . Chem. , 2007 , 79 : 4852 —4859
[19 ]  Pieken W, Olsen D B , Benseler F , et al . Science , 1991 , 253 :314 —317
[20 ]  Radi A E , AceroSanchez J L , Baldrich E , et al . J . Am. Chem.Soc. , 2006 , 128 : 117 —124
[21 ]  Huang C C , Chiu S H , Huang Y F , et al . Anal . Chem. , 2007 ,79 : 4798 —4804
[22 ]  Liu J W, Lu Y. J . Am. Chem. Soc. , 2007 , 129 : 8634 —8643
[23 ]  Shlyahovsky B , Li D , Weizmann Y, et al . J . Am. Chem. Soc. ,2007 , 129 : 3814 —3815
[24 ]  仲志鸿(Zhong Z H) , 羊小海( Yang X H) , 王柯敏(Wang K M) . 生命科学研究(Life Sci . Research) , 2006 , 10 : 206 —209
[25 ]  徒永华(Tu Y H) , 程圭芳(Chen G F) , 林莉(Lin L) . 高等学校化学学报(Chem. J . Chinese Univ. ) , 2006 , 27 : 2266 —2270
[26 ]  张迟(Zhang C) , 李柏生(Li B S) , 赵立凡(Zhao L F) . 公共卫生与预防医学(J . Public Health Preventive Med. ) , 2006 , 17 :26 —28
[27 ]  徐大炜(Xu D W) , 许丹科(Xu D K) . 化学传感器(Chem.Sens. ) , 2005 , 25 : 20 —21
[28 ]  Xiao Y, Lubin A A , Heeger A J , et al . Angew. Chem. Int . Ed. ,2005 , 44 : 5456 —5459
[29 ]  Yoshizumi J , Kumamoto S , Nakamura M, et al . Analyst , 2008 , 133(3) : 323 —325
[30 ]  Bang G S , Cho S , Kim B G. Biosens. Bioelectron. , 2005 , 21 :863 —870
[31 ]  Zhang Y L , Huang Y, Jiang J H , et al . J . Am. Chem. Soc. ,2007 , 129 : 15448 —15449
[32 ]  Wu Z S , Guo M M, Zhang S B , et al . Anal . Chem. , 2007 , 79 :2933 —2939
[33 ]  Feng K, Sun C , Kang Y, et al . Electrochem. Commun. , 2008 ,10 : 531 —535
[34 ]  Baker B R , Lai R Y, Wood M S , et al . J . Am. Chem. Soc. ,2006 , 128 : 3138 —3139
[35 ]  Li X, Shen L , Zhang D , et al . Biosens. Bioelectron. , 2008 , 23 :1624 —1630
[36 ]  Xu D , Xu D , Yu X, et al . Anal . Chem. , 2005 , 77 : 5107 —5113
[37 ]  Kim Y S , Jung H S , Matsuura T, et al . Biosens. Bioelectron. ,2007 , 22 : 2525 —2531
[38 ]  Rodriguez M C , Kawde A N , Wang J . Chem. Commun. , 2005 ,4267 —4269
[39 ]  Centi S , Tombelli S , Minunni M, Mascini M. Anal . Chem. , 2007 ,79 : 1466 —1473
[40 ]  Cheng A K H , Ge B , Yu H Z. Anal . Chem. , 2007 , 79 : 5158 —5164
[41 ]  Floch F L , Ho H A , Leclerc M. Anal . Chem. , 2006 , 78 : 4727 —4731
[42 ]  Zuo X, Song S , Zhang J , Pan D , Wang L , Fan C. J . Am. Chem.Soc. , 2007 , 129 : 1042 —1043
[43 ]  Hansen J A , Wang J , Kawde A N , Xiang Y, Gothelf K V , Collins G. J . Am. Chem. Soc. , 2006 , 128 : 2228 —2229
[44 ]  Radi A E , Sanchez J L A , Baldrich E , O’Sullivan C K. Anal .Chem. , 2005 , 77 : 6320 —6323
[45 ]  Paleˇcek E. Bioelectrochem. Bioenerg. , 1986 , 15 : 275 —295
[46 ]  Paleˇcek E , KoláV , Jelen F , Heinemann V. Bioelectrochem. Bioenerg. , 1990 , 23 : 285 —299
[47 ]  Ye Y K, Ju H X. Biosens. Bioelectron. , 2005 , 21 : 735 —741
[48 ]  庞代文(Pang D W) , 齐义鹏(Qi Y P) , 王宗礼(Wang Z L) ,程介克(Cheng J K) . 化学通报(Chemistry) , 1994 , 2 : 1 —4
[49 ]  Shen L , Chen Z, Li Y H , Jing P , Xie S B , He S L , He P L , Shao Y H. Chem. Commun. , 2007 , 2169 —2171
[50 ]  Xiao Y, Piorek B D , Plaxco K W, Heeger A J . J . Am. Chem.Soc. , 2005 , 127 : 17990 —17991
[51 ]  Radi A E , O’Sullivan C K. Chem. Commun. , 2006 , 3432 —3434
[52 ]  Lai R Y, Plaxco K W, Heeger A J . Anal . Chem. , 2007 , 79 :229 —233
[53 ]  Mir M, Vreeke M, Katakis I. Electrochem. Commun. , 2006 , 8 :505 —511
[54 ]  Papamichael K I , Kreuzer M P , Guilbault G G. Sens. Actuators B ,2007 , 121 : 178 —186
[55 ]  Centi S , Messina G, Tombelli S , Palchetti I , Mascini M. Biosens.Bioelectron. , 2008 , 23 (11) : 1602 —1609
[56 ]  Ikebukuro K, Kiyohara C , Sode K. Biosens. Bioelectron. , 2005 ,20 : 2168 —2172
[57 ]  Polsky R , Gill R , Kaganovsky L , Willner I. Anal . Chem. , 2006 ,78 : 2268 —2271
[58 ]  Numnuam A , Chumbimuni-Torres K Y, Xiang Y, Bash R ,Thavarungkul P , Kanatharana P , Pretsch E , Wang J , Bakker E.Anal . Chem. , 2008 , 80 : 707 —712
[59 ]  郑静(Zheng J ) , 林莉(Lin L) , 程圭芳(Chen G F) , 王安宝(Wang A B) , 谭雪莲(Tan X L) , 何品刚(He P G) , 方禹之(Fang Y Z) . 中国科学B 辑: 化学( Sci . China Ser. B :Chem. ) , 2006 , 36 : 485 —492
[60 ]  Fu Y C , Xie Q J , Jia X E , Xu X H , Meng W H , Yao S Z. J .Electroanal . Chem. , 2007 , 603 : 96 —106
[61 ]  De-los-Santos-Alvarez N , Lobo-Castanon MJ , Miranda-Ordieres AJ ,Tun-Blanco P. J . Am. Chem. Soc. , 2007 , 129 : 3808 —3809
[62 ]  Xu D W, Han H H , He W, Liu Z H , Xu D K, Liu X J .Electroanalysis , 2006 , 18 : 1815 —1820
[63 ]  Schlecht U , Malave A , Gronewold T M A , Tewes M, Lohndorf M.Biosens. Bioelectron. , 2007 , 22 : 2337 —2340
[64 ]  Xu Y, Yang L , Ye X Y, He P G, Fang Y Z. Electroanalysis ,2006 , 18 : 1449 —1456
[65 ]  Li B L , Wang Y L , Wei H , Dong S J . Biosens. Bioelectron. ,2008 , 23 : 965 —970
[66 ]  Lee J A , Hwang S , Kwak J , Park S I , Lee S S , Lee K C. Sens.Actuators B , 2008 , 129 : 372 —379
[67 ]  Elbaz J , Shlyahovsky B , Li D , Willner I. ChemBioChem. , 2008 ,9 : 232 —239
[68 ]  Zayats M, Huang Y, Gill R , Ma C , Willner I. J . Am. Chem.Soc. , 2006 , 128 : 13666 —13667

[1] Wei Yan, Liu Zhonggang, Gao Chao, Wang Lun, Liu Jinhuai, Huang Xingjiu. Electrochemical Sensors and Biosensors Based on Nanomaterials: A New Approach for Detection of Organic Micropollutants [J]. Progress in Chemistry, 2012, 24(04): 616-627.
[2] Wu Cuichen, Hu Jia, Zou Yuan, Wang Chi, Liu Jie, Yang Chaoyong. Application of Aptamers in Biomedicine [J]. Progress in Chemistry, 2010, 22(08): 1518-1530.
[3] Qu Feng Liu Yun Ren Xiaomin Zhao Xinying Zhang Jinghua. Application of Capillary Electrophoresis in Aptamers Study and Aptamers Selection [J]. Progress in Chemistry, 2009, 21(0708): 1576-1582.
[4] . Aptamer-Based Biosensor [J]. Progress in Chemistry, 2009, 21(04): 732-738.
[5] Qi Honglan,Zhang Chengxiao**. Applications of Nanoparticles in Electrochemical DNA Biosensors [J]. Progress in Chemistry, 2005, 17(05): 911-915.
Viewed
Full text


Abstract

Aptamer-Based Electrochemical Biosensors