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Progress in Chemistry 2009, Vol. 21 Issue (04): 687-695 Previous Articles   Next Articles

• Review •

Microfluidic Chip-Based Immunoassay

Leng Chuan1;  Zhang Xiaoqing2;  Ju Huangxian1**   

  1. (1. Key Laboratory of Analytical Chemistry for Life Science, Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China; 2. Key Laboratory of Clinical Laboratory Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing 400016, China)
  • Received: Revised: Online: Published:
  • Contact: Ju Huangxian E-mail:hxju@nju.edu.cn
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With the continuous development in microfluidic fabrication technology, microfluidic analysis has evolved from a concept to one of research frontiers in last twenty years. The immunoassay methods based on microfluidic devices have also made great progress. Such devices consist of microchannels for transporting fluids integrated with part or all of the necessary components of an immunoassay procedure. Microfluidic technology improves greatly the analytical performance of immunoassays by reducing the consumption of reagents, decreasing the analysis time, and developing automation. This review focuses on the development and classification of microfluidic immunoassays, and the characteristics of each type of chips and their performances are also discussed．

Contents
1 Introduction
2 Classification and characteristics of microfluidic chip-based immunoassay
3 Homogeneous and heterogeneous immunoassay on microfluidic chips
3.1 Homogeneous immunoassay
3.2 Hetergeneous immunoassay
4 Perspectives

Key words: microfluidics, immunoassay, immunosensors, chips

CLC Number: 

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Abstract

Microfluidic Chip-Based Immunoassay