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Progress in Chemistry 2009, Vol. 21 Issue (01): 55-62 Previous Articles   Next Articles

• Special issues •

Novel Immunosuppression Stemming from the Selective Activity of Chinese Herbal Grugs

Xu Qiang*;Sun Yang   

  1. (State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China)
  • Received: Revised: Online: Published:
  • Contact: Xu Qiang E-mail:qiangxu.nju@163.com
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Despite the marked progress in immunology, the research and development of the remedies for immune diseases really dropped behind those for others. The broad-spectrum inhibition on various cells or tissues is the main problem existing in current immunosuppressive agents. Such low selectivity of the drug effect usually leads to the discontinuity of therapy for patients, who should receive long-term treatment. Thus, a new pathway is required for the discovery of remedies for immune diseases. This review summarizes some results on Chinese herbal drugs and their principles obtained in author's laboratory after an overview of the current immunosuppressants for comparison. A novel regulation on immune response, selective inhibition of activated T lymphocytes, and its possible application as a selective immunosuppressive therapy are suggested.

Contents
1 Introduction
2 The present situation of immunosuppressive agents
2.1 Glucocorticoids
2.2 Cytotoxic agents
2.3 New generation of immunosuppressive agents
3 The discovery of novel immunosuppressants from Chinese herbal medicines
4 The selectively immunosuppressive activity and their mechanisms of the extract from Rhizoma Smilacis Glabrae and its active principle astilbin 4.1 The selective inhibition of the extract from Rhizoma Smilacis Glabrae on T cell-mediated immune response
4.2 Astilbin is the main active principle in the extract from Rhizoma Smilacis Glabrae 4.3 The mechanisms underlying the selective immunosuppression of astilbin
4.4 The metabolite of astilbin in vivo
4.5 The other flavonoids in Rhizoma Smilacis Glabrae
5 The prospect

Key words: selective immunosuppression, Chinese herbal drugs, Rhizoma smilacis glabrae, astilbin

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