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Progress in Chemistry 2009, Vol. 21 Issue (01): 30-46 Previous Articles   Next Articles

• Special issues •

Symbionts, an Important Source of New Bioactive Natural Products

Ge Huiming;Tan Renxiang**   

  1. (Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China)
  • Received: Revised: Online: Published:
  • Contact: Tan Renxiang E-mail:rxtan@nju.edu.cn
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Symbionts are microorganisms living inside hosts (mostly multicellucar organisms) during a variable period of their life. The natural products produced by symbionts is poorly investigeted since the presence and/or productivity of these microorganisms have been neglected for a long duration. However, during the long-time co-evolution with their hosts, symbionts have more chances to acquire unique traits in their biochemistry, physiology and secondary metabolite production. The review summarizes the major progress in symbiont generated natural products, being chemically inspiring and biologically potent secondary metabolites.

Contents
1 Endophytes
1.1 Alkaloids
1.2 Terpenoides
1.3 Steroids
1.4 Isocoumarin
1.5 Anthraquinones
1.6 Cyclopeptides
1.7 Phenylpropanoids & lignans
1.8 Esters and lactones
1.9 Phenols
1.10 Others
2 Microbes associated with insect
2.1 Alkaloids
2.2 Terpenoids
2.3 Steroids
2.4 Quinones
2.5 Peptides
2.6 Lactones
2.7 Phenols
2.8 Others
3 Microbes isolated from sponge
3.1 Alkaloids
3.2 Peptides
3.3 Quinones
3.4 Lactones
3.5 Others
4 Other symbionts
5 Conclusions

Key words: symbiotic microbes, natural products, bioactive metabolites, endophytes, microbes associated with insect, microbes isolated from sponge

CLC Number: 

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