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Progress in Chemistry 2009, Vol. 21 Issue (01): 200-209 Previous Articles   Next Articles

• Review •

Microchip Capillary Electrophoresis with Amperometric Detection

Wang Yurong;Chen Hengwu**   

  1. (Institute of Micro Analytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, China)
  • Received: Revised: Online: Published:
  • Contact: Chen Hengwu E-mail:hwchen@zju.edu.cn
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Micochip capillary electrophoresis with amperometric detection (μCE-AD) has attracted increasing interest due to the features offered by amperometric detection, such as high sensitivity, low cost and power consumption, inherent miniaturization and portability, and compatibility with microfabrication technologies. This article reviews on recent advances in μCE-AD systems, including microchip design, fabrication of integrated electrodes, elimination of high-voltage interference with the detection. Field-non-isolating detection, electrode array and channel array, application of chemically modified electrodes, novel approaches for sample injection, and on-chip sample preparation are also discussed. The future development of the μCE-AD is foreseen.

Contents
1 Introduction
2 Design of μCE-AD chip
3 Fabrication of integrated electrodes
4 Elimination of high-voltage interference with the detection
5 Field-non-isolating detection
6 Electrode array and channel array
7 Chemically modified electrodes
8 Novel approaches for sample injection
9 On-chip sample preparation
10 Future prospects

Key words: amperometric detection, microfluidic chip, capillary electrophoresis chip

CLC Number: 

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