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Progress in Chemistry 2009, Vol. 21 Issue (01): 100-105 Previous Articles   Next Articles

• Special issues •

Strategies on the Quality Control and DMPK Studies of Traditional Chinese Medicine

Ye Min; Guo Dean*   

  1. (School of Pharmaceutical Sciences, Peking University, Beijing 100191, China)
  • Received: Revised: Online: Published:
  • Contact: Guo Dean E-mail:gda@bjmu.edu.cn
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Quality control is critically important for the safety and efficacy of traditional Chinese medicine. DMPK (drug metabolism and pharmacokinetic) studies facilitate the clarification of the mechanism of action of traditional Chinese medicine. In this paper , we discuss the current barriers in the quality control and DMPK studies of traditional Chinese medicine by using our studies on toad venom (Chan-Su) as example. It is concluded that the combination of full assignments of the chemical fingerprint and the simultaneous quantitation of multiple compounds is a feasible way for the comprehensive quality control of traditional Chinese medicines. Liquid chromatographyPmass spectrometry (LCPMS) will play an important role in chemistry and DMPK studies of traditional Chinese medicine. The chemical fingerprints of traditional Chinese medicines should be correlated with their pharmacological activities so as to establish a reasonable traditional Chinese medicine quality evaluation system. Structural modification could be valuable for natural product-based drug discovery.

Contents
1 　Introduction
2 　Studies on the traditional Chinese medicine Chan-Su (toad venom)
2. 1 　Chemical constituents of toad venom
2. 2 　Chemical fingerprint of toad venom and peak interpretation
2. 3 　Quantitative analysis of major bufadienolides in toad venom
2. 4 　In vivo metabolism of toad venom
2. 5 　Structural modification of bufadienolides
3 　Perspectives
3. 1 　How to study the chemistry of traditional Chinese medicines ?
3. 2 　How to establish the chemical fingerprint of traditional Chinese medicines ?
3. 3 　How to study the DMPK of traditional Chinese medicines ?
3. 4 　How to do the structural modification of natural products ?
4 　Conclusions

Key words: traditional Chinese medicines, quality control, DMPK studies, fingerprinting

CLC Number: 

[ 1 ] 　Ye M, Guo H , Guo H Z, et al . J . Chromatogr. B , 2006 , 838 (2) :86 —95
[ 2 ] 　Ye M, Guo D A. Rapid Commun. Mass Spectrom. , 2005 , 19 (13) :1881 —1892
[ 3 ] 　Liang Y, Liu A H , Qin S , et al . J . Pharm. Biomed. Anal . , 2008 ,46 : 442 —448
[ 4 ] 　Ye M, Dai J G, Guo H Z, et al . Tetrahedron Lett . , 2002 , 43(47) : 8535 —8538
[ 5 ] 　Ye M, Han J , Guo H Z, et al . Magn. Reson. Chem. , 2002 , 40(12) : 786 —788
[ 6 ] 　Ye M, Ning L L , Zhan J X, et al . J . Mol . Catal . B : Enzym. ,2003 , 22 (1P2) : 89 —95
[ 7 ] 　Ye M, Han J , Tu G Z, et al . J . Nat . Prod. , 2005 , 68 ( 4) :626 —628
[ 8 ] 　Ye M, Han J , An D G, et al . Tetrahedron , 2005 , 61 ( 37) :8947 —8955
[ 9 ] 　Ye M, Guo D A. Nat . Prod. Res. , 2008 , 22 (1) : 26 —30
[10 ] 　Ye M, Qu GQ , Guo H Z, et al . Appl . Environ. Microbiol . , 2004 ,70 (6) : 3521 —3527
[11 ] 　Ye M, Guo D A. J . Biotechnol . , 2005 , 117 (3) : 253 —262
[12 ] 　Ye M, Qu GQ , Guo H Z, et al . J . Steroid Biochem. Mol . Biol . ,2004 , 91 (1P2) : 87 —98
[13 ] 　Ye M, Yan Y N , Guo D A , et al . Rapid Commun. Mass Spectrom. , 2005 , 19 (11) : 1469 —1484
[14 ] 　Ye M, Han J , Chen H B , et al . J . Am. Soc. Mass Spectrom. ,2007 , 18 (1) : 82 —91
[15 ] 　Ye M, Guo D A , Ye G, et al . J . Am. Soc. Mass Spectrom. ,2005 , 16 (2) : 234 —243
[16 ] 　Ma X C , Cui J , Zheng J , et al . J . Mol . Catal . B : Enzym. , 2007 ,48 : 42 —50
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