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Progress in Chemistry 2008, Vol. 20 Issue (12): 2045-2052 Previous Articles   Next Articles

• Review •

Fluorescent Labeling Chemistry in Single Cell Analysis

Zhu Lanlan; Yin Xuefeng**   

  1. (Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310027, China)

  • Received: Revised: Online: Published:
  • Contact: Yin Xuefeng
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The technical requirements for the determination of the chemical composition of individual cells are strict due to the complex composition and minute amount of analyte present in a single cell. Due to its high sensitivity, fluorescence detection is one of the dominant detection techniques used for single cell analysis. However, a large number of compounds found in single cells are nonfluorescent. In order to introduce derivatization reagents into cells to label intracellular analytes without evident dilution, considerable efforts on derivatization of intracellular contents have been made. The intralellular labeling methods developed for single cell analysis are summarized in this review, including cell itself acting as a microreaction chamber for derivatization, dericatization mediated by liposome or polyethylene glycol to increase permeabilization of cell membrane, on- and post-column derivatization during single cell analysis with capollary electrophoresis or microchip electrophoresis and labelling of cells with quantum dots. Their principles, characters and applications in single cell analysis are also described in detail.

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