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Progress in Chemistry 2008, Vol. 20 Issue (12): 2034-2044 Previous Articles   Next Articles

• Review •

Photolysis of Caged Compounds and Its Applications to Chemical Biology

Meng Xiangming1,2; Chen Xiaoyun1; Fu Yao1**; Guo Qingxiang1**   

  1. (1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, China; 2. Department of Chemistry, Anhui University, Hefei 230039, China)
  • Received: Revised: Online: Published:
  • Contact: Fu Yao; Guo Qingxiang
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The recent development in biomedicine demands more accurate understanding of biological processes at the molecular level. In order to observe the chemical processes of living cells or tissues in a real-time fashion with high space resolution, it is necessary to develop methods to selectively activate molecular probes. Confocal laser technology provides a very efficient method for activation of the molecular probes without any injury to tissues. Based on this technology, a series of photon switch which have biological applications have been realized. By now, the development of caging groups for photon switch has become an interesting research area. In this paper, we summarize the popular one-photon and two-photon photo-removable groups including nitrobenzene, coumarin, quinolines, indole derivatives, etc. The mechanism of these caging groups using as photon switch is surveyed. The application and the prospects of these groups in chemical biology are also discussed.
Key words: photon switch, confocal laser technology, caging groups

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