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Progress in Chemistry 2008, Vol. 20 Issue (12): 1998-2011 Previous Articles   Next Articles

• Review •

Heparin for Growth Factor Delivery systems

Ding Shanshan1 Cui Yuanlu1 Gong Zheng2 Yin Yuji2** Yao Kangde2

  

  1. (1. Research Center of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique- Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; 2. School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China)

  • Received: Revised: Online: Published:
  • Contact: Yin Yuji
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Heparin, a sulfated polysaccharide and a representative antithrombotic drug, has special binding affinity with a number of biologically important proteins such as growth factors and cytokines, and thereby plays an essential role in the regulation of various biological signaling. Heparin-containing matrices or delivery systems immobilized and protected high-affinity heparin-binding growth factors from degradation, release growth factor in a sustained manner, increased both the stability and activity of the growth factor. In this review, we summarized recently developed hydrogel matrices and scaffolds which contained heparin for growth factor delivery in tissue engineering.
Key words: heparin, growth factors, hydrogel, release, bioactivity

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Abstract

Heparin for Growth Factor Delivery systems