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Progress in Chemistry 2008, Vol. 20 Issue (11): 1804-1809 Previous Articles   Next Articles

• Review •

The Research of Functional Polymeric Gene Vector

Hua Yuan Jie Ren   

  • Received: Revised: Online: Published:
  • Contact: Hua Yuan
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Developing of safe、efficient gene delivery systems is one of the most critical points for gene therapy. Polymeric non-viral gene carriers having good properties, such safety、easy to design、inexpensive, have been utilized to deliver therapeutic genes in vivo. However, traditional polymers as gene vector only have a few function can not meet gene therapy requirement, so it is necessary to decorate traditional polymer gene vectors, getting ideal gene vectors with multi-function. This review focuses on the development and means of the modification of polymeric gene vector making them have multi-function—the ability to maintain stability outside of cell、the ability of cell entrance、the ability of endosome escape and the ability of nuclear membrane traversing, at last, we highlight the main challenges that remain and the future direction of polymeric vectors research.
Key words: Gene therapy, Vector, Functionalizing

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[1 ] Dufes C,Uchegbu L F,Schatzlein A G.Adv.Drug Delivery Rev.,2005 ,57:2177 —2202
[2 ] Moriguchi R,Kogure K,Akita H,etal.Int.J.Pharm.,2005 ,301:277 —285
[3 ] Gao Y,Gu W W,Chen L L,etal.J.Controlled Rel.,2007 ,118:381 —388
[4 ] VanCraenenbroeck K,Vanhoenacker P,Haegeman G.Eur.J.Biochem.,2000 ,267:5665 —5678
[5 ] Hacein-Bey-Abina S,VonKalle C,Schmidt M,etal.N.Engl.J.Med.,2003 ,348:255 —256
[6 ] Wu G Y,Wu C H.Bio.Chem.,1987 ,262:4429 —4432
[7 ] Wolfert M A,Dash P R,Nazarova O,etal.Bioconjugate Chem.,1999 ,10:993 —1004
[8 ] Kim Y H,Park J H,Lee M,etal.J.Controlled Rel.,2005 ,103:209 —219
[9 ] Godbey W T,Wu K K,Mikos A G.Biomaterials,2001 ,22:471 —480
[10 ] Thanou M,Verhoef J C,Junginger H E.Adv.Drug Delivery Rev.,2001 ,50:91 —101
[11 ] Tsutsumi T,Hirayama F,Uekama K,etal.J.Contolled Rel.,2007 ,119 (3) :349 —359
[12 ] Messai I,Lamalle D,Munier S,etal.Colloids Surf.A,2005 ,255:65 —72
[13 ] Kichler A.Gene Med.,2004 ,6 (1) :3 —10
[14 ] Kaul G,Amiji M.Pharm.Res.,2005 ,22:951 —961
[15 ] Lee H,Jeong J H,Park T G.J.Controlled Rel.,2001 ,76:183 —192
[16 ] Mishra S,Webster P,Davis M E.Eur.J.Cell Biol.,2004 ,83:97 —111
[17 ] He G S,Ma L L,Pan J,etal.Int.J.Pharm.,2007 ,334:48 —55
[18 ] Harada A,Togawa H,Kataoka K.Eur.J.Pharm.Sci.,2001 ,13:35 —42
[19 ] Chen J J,Tian B N,Yin X,etal.J.Biotechnol.,2007 ,130:107 —113
[20 ] Luo D,Saltaman W M.Nat.Biotechnol.,2000 ,18 (1) :33 —37
[21 ] Chuah M K,Collen D,Vanden D T.Curr.GeneTher.,2003 ,3:527 —543
[22 ] Nah J W,Yu L,Han S O,etal.J.Control.Release,2002 ,78:273 —284
[23 ] Han M,Chen P Q,Yang X Z.Polymer,2005 ,46:3481 —3488
[24 ] Elfinger M,Maucnsch C,Rudolph C.Biomaterials,2007 ,28:3448 —3455
[25 ] Witlox M A,Lamfers M L,Wuisman D T,etal.Bone,2007 ,40:797 —812
[26 ] Merdan T,Callahan J,Petersen H,etal.Bioconjugate Chem.,2003 ,14:989 —996
[27 ] Yoo H S,Park T G.J.Controlled Release,2004 ,96:273 —283
[28 ] Park E K,Kim S Y,Lee S B,etal.J.Controlled Release,2005 ,109:158 —168
[29 ] Lee Y K.Macromol.Res.,2006 ,14:387 —393
[30 ] Shmeeda H,Mak L,Tzemach D,etal.Mol.CancerTherap.,2006 ,5:818 —824
[31 ] Cho K C,Kim S H,Jeong J H,etal.Macromol.Biosci.,2005 ,5:512 —519
[32 ] Benns J M,Maheshwari A,Furgeson D Y,etal.J.Drug Target,2001 ,9:123 —139
[33 ] 苏惠霜( Su H S ) , 王一飞( Wang Y F ) . 遗传( Hereditas) ,2006 ,28 (10) :1321 —1324
[34 ] Oishi M,Kazunori K,Nagasaki Y.Bioconjugate Chem.,2006 ,17:677 —688
[35 ] Ihm J E,Han K O,Han I K,etal.Bioconjug.Chem.,2003 ,14(4) :707 —708
[36 ] Grime D,Kay M A.Curr.Gene Ther.,2003 ,3 (4) :281 —304
[37 ] Kichler A,Mechtler K,Behr J P,etal.Bioconjugate Chem.,1997 ,8 (2) :213 —221
[38 ] Wyman T B,Nicol F,Zelphati O,etal.Biochemistry,1997 ,36(10) :3008 —3017
[39 ] Boeckle S,Wagner E,Ogris M,etal.J.Gene Med.,2005 ,7(1) :105 —118
[40 ] Murthy N,Chang I,Stayton P,etal.Macromol.Symp.,2001 ,172(1) :49 —56
[41 ] Ludtke J J,Zhang G F,Sebestyen M G,etal.Mol.Ther.,2002 ,5:579 —588
[42 ] Dean D A,Strong D D,Zimmer W E.Gene Ther.,2005 ,12(11) :881 —890
[43 ] Kim H H,Choi H S,Yang J M,etal.Int.J.Pharm.,2007 ,335:70 —78
[44 ] Yoo H S,Jeong S Y.Eur.J.Pharm.Biopharm.,2007 ,66:28 —33
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