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Progress in Chemistry 2008, Vol. 20 Issue (11): 1798-1803 Previous Articles   Next Articles

• Review •

Progress of the Applications of Carbon Nanotubes in Drug and Gene Delivery

Hua He   

  • Received: Revised: Online: Published:
  • Contact: Hua He
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At present, many domestic and foreign research teams are committed to develop new and efficient drug and gene transfer systems for improving the pharmacological effects of many classes of therapeutic molecules and reduce their toxicity. Within the family of nanomaterials, carbon nanotubes (CNTs) is increasingly attracting attention. Two key advantages of functionalized carbon nanotubes ( f-CNTs) are their strong ability to translocate through plasma membranes and low toxicity, allowing their application in drug and gene transfer system. CNTs can form stable covalent bonds formations or supramolecular assemblies based on noncovalent interactions with active molecules such as peptide, protein, nucleic acid and drug. And then deliver them into specific cells, tissues and organs to express special biological functions. For this research hot spot, we reviewed the recent domestic and international research developments on the application of carbon nanotubes in drug and gene transfer systems, and discussed its toxicity, hope for providing some references for the researchers in this field.
Key words: carbon nanotubes, functionalization, nanovectors, drug delivery, gene delivery, toxicity

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