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Progress in Chemistry 2008, Vol. 20 Issue (11): 1788-1797 Previous Articles   Next Articles

• Review •

Progress in KARI and its Inhibitors

刘幸海 XingHai Liu   

  • Received: Revised: Online: Published:
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Ketol-acid reductoisomerase (KARI; EC 1.1.1.86) is an attractive targets for argochemical discovery because it catalyzes the second important step in the biosynthesis of the branched chain amino acid which exist in higher plants and certain fungi only and not in animals. Thus it is an ideal target from which to design non-toxic KARI-inhibitors as potential novel herbicides and antibiotics. The X-ray crystallography of the KARI enzyme, inhibitors and their inhibit mechanism, and theoretical research are reviewed.

Key words: KARI, inhibitors, SAR, drug design

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Abstract

Progress in KARI and its Inhibitors