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Progress in Chemistry 2008, Vol. 20 Issue (11): 1768-1778 Previous Articles   Next Articles

• Review •

Application of Synchrotron FTIR Techniques in Biomedical Fields

Jiaping Yan   

  • Received: Revised: Online: Published:
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Synchrotron infrared light source, characterized with broadband, high brightness and resolution is widely used in biomedical fields. With the progress in imaging technique of FTIR microscopy, the scientists could detect biochemical changes in vivo with synchrotron FTIR in subcellular scale and preserved the cells in life feature. By analysis the protein, nucleic acid and phospholipid components in animal and botanic tissues and cells qualitatively and quantitatively, the pathological changes of bone, the neurodegeneration, the progress of cancer cells and the nutrition in plants could be well understood. Furthermore, the controlled release of drugs and other biochemical processes could also be monitored by synchrotron FTIR. It is worth noting that the intermolecular vibrations of biomolecular assemblies lie in the long wavelength, the so-called far infrared region, where synchrotron FTIR could provide higher signal-to-noise ratio spectra compared with conventional FTIR with global light source.

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