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Progress in Chemistry 2008, Vol. 20 Issue (11): 1699-1707 Previous Articles   Next Articles

• Review •

Chemical Synthesis of Rebeccamycin and Its Analogues

  

  • Received: Revised: Online: Published:
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Rebeccamycin, as a new natural antibiotics, is of great interest to researchers for its potential antitumor activity. However, it cannot be directly utilized as a drug for some disadvantages by itself. To search for better lead compounds, the structure of rebeccamycin was modified or altered, and large numbers of its analogues have been obtained, via biosynthesis and chemical synthesis. Herein, we will present a review of recent progress in chemical synthesis of rebeccamycin and its analogues.
Key words: rebeccamycin, antibiotics, lead compounds, chemical synthesis

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