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Progress in Chemistry 2008, Vol. 20 Issue (11): 1675-1686 Previous Articles   Next Articles

• Review •

Proline-Catalyzed Asymmetric Reactions

  

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Proline has been gradually recognized as a simple , commercial and cheap chiral catalyst for many asymmetric reactions. The paper reviews recent advances in the development of direct proline-catalyzed asymmetric reactions including Aldol reaction, Mannich reaction, Michael reation, Diels-Alder reaction, direct α-amination reaction, α-oxo amination reaction, Baylis-Hillman reaction, reduction reaction and oxidation reaction. It also puts forward the future application of proline.

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Abstract

Proline-Catalyzed Asymmetric Reactions