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Progress in Chemistry 2008, Vol. 20 Issue (10): 1628-1634 Previous Articles   

• Review •

Surface Modification of Biomedical Materials with Cell Membrane Mimetic Structures

Gong Ming; Yang Shan; Zhang Shiping; Gong Yongkuan**   

  1. (Key Laboratory of Chemistry of Synthetic and Natural Functional Molecules of Ministry of Education, Department of Chemistry, Northwest University, Xi’an 710069, China)

  • Received: Revised: Online: Published:
  • Contact: Gong Yongkuan
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The cell membrane establishes an important paradigm for the surface modification of implantable devices because of its intrinsic biocompatibility. Numerous researches have suggested that the biocompatibility of materials can be improved remarkably after modified with phosphorylcholine group, which is the major head group of the phospholipid of the cells outer membrane. This kind of membrane mimetic surfaces shows practical and scientifically importance in variety of biomaterials. The methods of fabricating membrane mimetic surfaces are categorized and the resulting surface properties are discussed along with introducing the representative researches. Several important mechanisms of biocompatibiliy are also summarized. Finally, the prospects of the research on membrane mimetic surfaces are suggested.

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