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Progress in Chemistry 2008, Vol. 20 Issue (0708): 1102-1107 Previous Articles   Next Articles

• Review •

Advances in the Synthesis of Thiocarbamates

Zhang Xiaopeng1,2 Jing Huanzhi1 Miao Jianghuan1 Lu Shiwei2**   

  1. (1.College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, China; 2. National Engineering Research Center for Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116011, China)
  • Received: Revised: Online: Published:
  • Contact: Lu Shiwei
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Thiocarbamates, a type of compounds containing many functional groups and possessing bioactivity, have been widely applied in medicine, biology and agricultural chemicals. In this paper, the main methods to thiocarbamates such as hydrolysis or alcoholysis of thiocyanate, rearrangement reaction, phosgene derivatives method and carbonylation of nitro compounds or amines are summarized. Their advantages and disadvantages are also compared. It is pointed out that selenium-catalyzed carbonylation of nitro compounds or amines with thiols to thiocarbamates is a promising method which is characterized by benign environment, high atomic economy and “one-pot” approach.

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